Cpvit E

As a dietary supplement

• Vitamin E deficiency resulting from impaired absorption (e.g., in cystic fibrosis, chronic cholestasis, Crohn's disease, abetalipoproteinaemia, and other gastrointestinal malabsorption conditions)
• Increased requirements due to a diet rich in polyunsaturated fats
• Support for healthy hair and skin
• As an antioxidant
• Hemolytic anemia due to Vitamin E deficiency

Therapeutic use

• Cardiovascular disease
• Heavy metal poisoning
• Hepatotoxin poisoning
• Hemolytic anemia
• Oxygen therapy
• Nutritional deficiency states

Dosage should be individualised according to the indication and the patient's condition. The following are general reference ranges:

Adults (supplemental)

Males: approximately 10 mg alpha-tocopherol equivalents (alpha-TE) per day. Females: approximately 8 mg alpha-TE per day. Pregnant women: approximately 10 mg alpha-TE per day. Breastfeeding women: 11–12 mg alpha-TE per day.

Children (supplemental)

Birth to 3 years: 3–6 mg alpha-TE per day. 4–10 years: approximately 7 mg alpha-TE per day.

Therapeutic (deficiency due to malabsorption — adults)

Cystic fibrosis: 100–200 mg daily. Abetalipoproteinaemia: 50–100 mg/kg daily.

Therapeutic (deficiency due to malabsorption — children)

Cystic fibrosis, under 1 year: 50 mg daily. Cystic fibrosis, 1 year and over: 100 mg daily. Infants with cholestasis: 150–200 mg/kg daily.

Serum alpha-tocopherol to cholesterol ratio should be maintained above 5.4 mg/g; levels should be monitored annually or 3–6 months after any dose adjustment. Always follow the prescribing physician's instructions.

Take orally. The chewable tablet should be chewed thoroughly before swallowing. May be taken once daily or as directed by a physician. Can be taken with or without food, although taking it with a fat-containing meal may improve absorption, as Vitamin E is a fat-soluble vitamin.

Vitamin E (alpha-tocopherol) is a fat-soluble vitamin and the body's principal lipid-soluble, chain-breaking antioxidant. It protects cell membranes and other lipid-containing structures — including low-density lipoproteins — from oxidative damage caused by free radicals.

Alpha-tocopherol acetate is an ester form of vitamin E that is hydrolysed in the gut to release the active alpha-tocopherol. It is absorbed from the gastrointestinal tract and widely distributed to body tissues. Excretion occurs slowly via bile and urine as metabolites.

Beyond its antioxidant role, Vitamin E supports immune function, promotes nitric oxide synthesis, helps maintain cell membrane stability, reduces blood viscosity, and protects vitamins A and carotenoids from oxidation.

At recommended doses, Vitamin E is generally well tolerated. The following effects have been reported, primarily at high doses:

Gastrointestinal:

• Diarrhoea and abdominal pain may occur with doses greater than 1 g daily.
• Nausea, stomach cramps.
• Haematological:
• Unusual bleeding or bruising — particularly at doses above 1000 mg per day or when taken with anticoagulants — due to Vitamin E's anticoagulant properties.
• Neurological / General (with prolonged high-dose use):
• Fatigue, headache.
• Serious risks with chronic high-dose supplementation:
• Increased risk of haemorrhagic stroke.
• Reports of increased all-cause mortality, cardiovascular events, and certain cancers at very high supplementation doses.

• Known hypersensitivity to Vitamin E (alpha-tocopherol acetate) or to any excipient in the formulation.
• Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption, or sucrase-isomaltase insufficiency (relevant where the formulation contains sucrose or related excipients).
• Use with caution — and only under medical supervision — in patients with bleeding disorders or those already receiving anticoagulant therapy, due to the increased risk of haemorrhage.

• Keep out of reach of children.
• Consult a healthcare provider before use, especially if you have pre-existing conditions such as heart failure, coagulation disorders, or a history of stroke.
• Patients taking anticoagulants or antiplatelet drugs should use Vitamin E only under medical supervision, with regular monitoring of prothrombin time and INR.
• Caution is advised in patients using estrogen-containing medications due to the potential increased risk of thrombosis.
• Do not exceed the recommended dose. The Tolerable Upper Intake Level for adults is 1000 mg of alpha-tocopherol per day from all sources combined.
• In premature infants weighing less than 1.5 kg, a higher incidence of necrotising enterocolitis has been noted with Vitamin E supplementation; use with caution in this population.

Premature infants: A higher incidence of necrotising enterocolitis has been reported in premature infants weighing less than 1.5 kg receiving Vitamin E supplementation. Use with caution and only under medical supervision in this group.

Patients with malabsorption syndromes: Conditions such as cystic fibrosis, chronic cholestasis, Crohn's disease, and abetalipoproteinaemia impair fat-soluble vitamin absorption. These patients may require higher therapeutic doses and regular monitoring of serum alpha-tocopherol levels.

Elderly: No specific dose adjustment is established, but the elderly may be at increased risk of drug interactions (e.g., with anticoagulants) and should be monitored accordingly.

Patients with bleeding disorders: Use only under close medical supervision due to Vitamin E's anticoagulant effect.

Pregnancy: There are insufficient safety data to recommend routine use during pregnancy, particularly during the first trimester. Use only if clearly indicated and under the supervision of a physician.

Lactation: It is not known whether alpha-tocopherol acetate at supplemental doses passes into breast milk in clinically significant amounts. Use during breastfeeding should be discussed with a healthcare provider. Daily requirements during lactation are approximately 11–12 mg alpha-TE per day.

Many adults have taken relatively large amounts of Vitamin E (400–800 mg per day) for months to years without apparent harm. The most significant risk of overdose is bleeding, which is uncommon unless the dose exceeds 1000 mg per day or the patient is concurrently taking warfarin or other anticoagulants.

Transient gastrointestinal disturbances (nausea, diarrhoea, abdominal pain) may occur at very high doses.

In the event of suspected overdose, seek immediate medical advice or contact a poison control centre. Treatment is supportive.

• Anticoagulants (e.g., warfarin, coumarin): Vitamin E may enhance anticoagulant effects and increase the risk of bleeding. Prothrombin time and INR should be monitored closely.
• Antiplatelet agents (e.g., aspirin): Combined use may further increase bleeding risk.
• Colestyramine (cholestyramine): May reduce gastrointestinal absorption of Vitamin E.
• Estrogens / estrogen-containing contraceptives: Concurrent use may increase the risk of thrombosis.
• Iron supplements: Vitamin E doses above 4.5 mg/kg per day may delay the red blood cell response in iron-deficient anaemic infants.
• Statins and niacin: High-dose Vitamin E supplementation may reduce the effectiveness of these cholesterol-lowering medications.
• Chemotherapy drugs: Vitamin E may interact with certain chemotherapy agents; use only under medical supervision during cancer treatment.

Store below 25°C. Keep in a tightly closed container, away from heat and moisture. Protect from direct sunlight. Keep out of reach of children.

What is the price of Cpvit E 200 mg in Bangladesh (BD)?

Cpvit E 200 mg price in Bangladesh is ৳2 per tablet. Prices may vary by pharmacy and are updated regularly on this page.

What is Cpvit E used for?

As a dietary supplement: - Vitamin E deficiency resulting from impaired absorption (e.g., in cystic fibrosis, chronic cholestasis, Crohn's disease, abetalipoproteinaemia, and other gastrointestinal malabsorption…

Is Cpvit E an antibiotic?

No, Cpvit E is not an antibiotic.