Alfa-E

As a dietary supplement

• Vitamin E deficiency resulting from impaired absorption (e.g., in Crohn's disease, cystic fibrosis, and other gastrointestinal malabsorption conditions)
• Increased vitamin E requirements due to a diet rich in polyunsaturated fats
• Support for healthy hair and skin
• Antioxidant protection against free radical damage
• Hemolytic anemia due to vitamin E deficiency

Therapeutic use

• Cardiovascular disease
• Heavy metal poisoning
• Hepatotoxin poisoning
• Hemolytic anemia
• Oxygen therapy
• Nutritional deficiency states
• Reduction of risk of age-related macular degeneration progression (in combination with other vitamins and minerals, in certain patients)

Doses should be directed by a physician. The following are standard reference ranges:

Adults (dietary supplement / deficiency prevention)

The recommended dietary allowance (RDA) is 15 mg daily. The tolerable upper intake level (UL) for adults is 1000 mg per day.

Vitamin E deficiency (therapeutic)

60–75 units daily, as directed by a physician.

Pediatric patients (dietary supplement)

• 1–3 years: 6 mg daily (upper limit 200 mg/day)
• 4–8 years: 7 mg daily (upper limit 300 mg/day)
• 9–13 years: 11 mg daily (upper limit 600 mg/day)
• 14–18 years: 15 mg daily (upper limit 800 mg/day)

Cystic fibrosis (special therapeutic dosing)

Infants: 40–50 units daily. Children over 8 years: 200–400 units daily, as directed by a physician.

Take with a meal to improve absorption. Do not exceed the recommended dose unless under medical supervision.

Chew the tablet thoroughly before swallowing. Take with a meal, as dietary fat significantly improves absorption of this fat-soluble vitamin. Taking multiple smaller doses throughout the day may improve absorption compared with a single large dose.

Vitamin E (alpha-tocopherol acetate) is a fat-soluble vitamin belonging to the antioxidant class. It protects cell membranes and other lipid-containing structures from oxidative damage caused by free radicals. By neutralising free radicals, it helps maintain the integrity of polyunsaturated fatty acids within cell membranes. Vitamin E also supports normal immune function and plays a role in blood clotting. Approximately 20–40% of an oral dose is absorbed from the gastrointestinal tract; absorption is enhanced when the supplement is taken with food containing fat.

Vitamin E is generally well tolerated at recommended doses. The following adverse effects have been reported:

• Common (particularly at higher doses):
• Fatigue
• Headache
• Gastrointestinal disturbances (gas, diarrhea)
• Blurred vision
• Elevated serum creatinine
• Serious (associated with high-dose or long-term supplementation):
• Unusual or prolonged bleeding or bruising (contact a doctor immediately)
• Increased risk of hemorrhagic stroke
• Long-term use may cause electrolyte changes that can lead to cardiac function disorders and muscle weakness
• Supplementation at 400 IU/day or above has been associated with a modest increase in all-cause mortality in certain populations

In infants: Necrotizing enterocolitis has been reported with high-dose supplementation.

Hypersensitivity to vitamin E (alpha-tocopherol acetate) or to any component of the formulation.

• Patients with bleeding disorders or vitamin K deficiency should use vitamin E with caution, as it may further impair coagulation.
• High-dose vitamin E supplementation should be discontinued at least one month before elective surgery to reduce the risk of perioperative bleeding.
• Long-term high-dose use may cause changes in blood electrolytes, potentially affecting cardiac and muscle function; periodic monitoring is advisable.
• Patients with pre-existing conditions such as heart failure, history of stroke, or coagulation disorders should use high-dose vitamin E only under medical supervision.
• Keep out of reach of children.
• Do not exceed the recommended dose without medical advice.

Premature neonates and infants: Vitamin E supplementation is particularly important in premature newborns, who are at risk of deficiency. High doses in infants carry a risk of necrotizing enterocolitis and should only be used under medical supervision.

Cystic fibrosis patients: Due to impaired fat-soluble vitamin absorption, higher therapeutic doses are required — 40–50 units daily for infants and 200–400 units daily for children over 8 years, under medical guidance.

Elderly patients: No specific dose adjustment is established, but caution is warranted with high-dose supplementation given the documented risk of increased all-cause mortality in older adults with certain underlying conditions.

Patients with malabsorption conditions (e.g., Crohn's disease, cystic fibrosis): Higher doses may be needed; dosing should be individualised and monitored by a physician.

Pregnancy: Vitamin E at RDA levels (15 mg per day) is generally considered acceptable during pregnancy, with no documented fetal risk at these doses. The RDA for pregnant women is 15 mg per day. High-dose supplementation during pregnancy has not been established as safe and should be avoided unless specifically directed by a physician.

Lactation: Vitamin E is excreted in breast milk. At RDA levels (approximately 19 mg per day during breastfeeding), it is considered safe for use while breastfeeding. Inform your healthcare provider if you are breastfeeding before taking any supplemental dose.

Adults generally tolerate oral doses of 100–800 mg per day without symptoms or evidence of toxicity. Exceeding the tolerable upper intake level (1000 mg per day in adults) over time may result in:

• Increased bleeding risk
• Changes in blood electrolytes
• Muscle weakness
• Liver damage

In the event of a suspected overdose, contact a Poison Control Centre immediately or seek emergency medical care. Unusual bleeding may be an early sign of toxicity.

Vitamin E has no known severe interactions with other drugs. However, the following interactions have been documented and should be discussed with a healthcare provider:

• Anticoagulants (e.g., warfarin): High-dose vitamin E supplementation may enhance anticoagulant effects and increase the risk of bleeding. At RDA levels, vitamin E does not significantly affect warfarin; however, megadoses may require dose adjustment.
• Antiplatelet agents (e.g., aspirin): Concurrent use with high-dose vitamin E may amplify the risk of bleeding.
• Iron preparations (e.g., ferrous sulfate, iron sucrose, polysaccharide iron): Moderate interaction; co-administration may affect absorption or activity of either agent.
• Vortioxetine: Moderate interaction has been documented.

Mild interactions have been reported with more than 60 other medications. Patients taking any regular medications should inform their healthcare provider before starting vitamin E supplementation.

Store at room temperature, away from excess heat and moisture. Keep the container tightly closed. Store out of reach of children.

What is the price of Alfa-E 200 mg in Bangladesh (BD)?

Alfa-E 200 mg price in Bangladesh is ৳5 per tablet. Prices may vary by pharmacy and are updated regularly on this page.

What is Alfa-E used for?

As a dietary supplement: - Vitamin E deficiency resulting from impaired absorption (e.g., in Crohn's disease, cystic fibrosis, and other gastrointestinal malabsorption conditions) - Increased vitamin E requirements due…

Is Alfa-E an antibiotic?

No, Alfa-E is not an antibiotic.