Biovit-E

As a dietary supplement

• Vitamin E deficiency resulting from impaired absorption
• Increased requirements due to a diet rich in polyunsaturated fats
• Support for healthy hair and skin
• As an antioxidant
• Hemolytic anemia due to Vitamin E deficiency

Therapeutic uses

• Cardiovascular disease
• Heavy metal poisoning
• Hepatotoxin poisoning
• Hemolytic anemia
• Oxygen therapy
• Nutritional deficiency states

Dosing should be individualised to the condition being treated. The following are general guidance ranges:

Adults

• Vitamin E deficiency: 60–75 IU daily (maximum 1000 IU daily)
• Cardiovascular disease: 400–800 IU daily
• Thalassemia: 800 IU daily
• Sickle-cell anemia: 400 IU daily
• Skin and hair health: 200–400 IU daily
• Cystic fibrosis: 100–400 IU daily

Children (deficiency)

• 1 month–12 years: 1 IU/kg/day
• Ages 1–3: maximum 200 IU daily
• Ages 4–8: maximum 300 IU daily
• Ages 9–13: maximum 600 IU daily
• Ages 14–18: maximum 800 IU daily

The chewable tablet should be chewed thoroughly before swallowing. It may be taken with or without food, but absorption is enhanced when taken with a meal containing fat, as Vitamin E is fat-soluble.

Vitamin E (alpha-tocopherol acetate) is a fat-soluble vitamin that functions primarily as a chain-breaking lipid antioxidant in the body. The acetate ester is hydrolysed in the gastrointestinal tract to release free alpha-tocopherol, which is then absorbed along with dietary fat via the lymphatic system and transported in the blood via lipoproteins.

In the liver, alpha-tocopherol is selectively bound by alpha-tocopherol transfer protein (α-TTP) and incorporated into very-low-density lipoproteins (VLDL) for distribution to extrahepatic tissues.

Alpha-tocopherol acts as a scavenger of peroxyl radicals, neutralising them and thereby interrupting the chain reaction of lipid peroxidation. This protects polyunsaturated fatty acids in cell membranes, as well as other oxidation-sensitive substances such as Vitamins A and C, from oxidative damage. It also inhibits platelet aggregation, monocyte adhesion, and vascular smooth muscle cell proliferation.

Vitamin E is generally well tolerated at recommended doses. Side effects are more likely at high doses.

• Common (at higher doses):
• Nausea
• Headache
• Diarrhoea
• Fatigue
• Visual disturbances
• Gastrointestinal upset
• Serious (with prolonged high-dose use, >1 g/day):
• Hypertension
• Myopathy
• Increased risk of bleeding due to antiplatelet effects
• At very high doses (≥400 IU/day over prolonged periods), an increased risk of all-cause mortality, haemorrhagic stroke, and cardiovascular events has been reported in certain patient populations

Vitamin E supplementation is contraindicated in individuals with a known hypersensitivity or allergy to Vitamin E or to any component of the formulation.

• Patients taking anticoagulants or antiplatelet drugs should use Vitamin E with caution due to increased bleeding risk.
• Patients taking oestrogen preparations should be advised of a potential increase in thrombosis risk.
• High-dose supplementation (≥400 IU/day) over prolonged periods may increase the risk of adverse cardiovascular outcomes in individuals with pre-existing heart disease, coagulation disorders, or a history of stroke; use with caution in these groups.
• High-dose Vitamin E may impair absorption of fat-soluble vitamins (A and K); monitor accordingly in patients relying on these nutrients.
• Keep out of reach of children.

Elderly: Antioxidant defence may be improved with low-dose Vitamin E supplementation in older adults. Elderly patients on anticoagulant or antiplatelet therapy require particular monitoring due to increased bleeding risk.

Renal impairment: No specific dose adjustment has been defined; however, chronic kidney disease is associated with elevated oxidative stress and altered alpha-tocopherol metabolism. Use with caution and under medical supervision.

Hepatic impairment: No specific dose adjustment has been defined. Hepatic binding proteins play a key role in Vitamin E distribution; patients with severe hepatic impairment should use under medical supervision.

Paediatric patients: Doses should be weight-based and age-appropriate (see Dosage). Intramuscular administration may be required in severe cholestasis or genetic malabsorption disorders.

Pregnancy: Vitamin E at recommended supplemental doses is generally considered safe during pregnancy. Higher doses beyond established safe limits have not been adequately studied in pregnant women; use at doses exceeding the recommended daily allowance should be under medical supervision.

Lactation: Vitamin E is present in breast milk. Supplementation at recommended doses is generally considered safe during breastfeeding. High-dose use during lactation has not been established as safe.

Vitamin E has a low acute toxicity profile; hypervitaminosis E is uncommon. Doses exceeding 1 g (1000 mg) per day have been associated with:

• Hypertension
• Fatigue
• Diarrhoea
• Myopathy

Prolonged use at very high doses may impair absorption of other fat-soluble vitamins and increase all-cause mortality risk. In the event of a suspected overdose, seek immediate medical attention or contact a poison control centre.

• Warfarin and anticoagulants: Vitamin E potentiates the anticoagulant effect of warfarin and similar agents, increasing the risk of bleeding. Close monitoring of coagulation parameters is recommended.
• Antiplatelet agents (e.g. aspirin): Concurrent use may further increase bleeding risk due to additive inhibition of platelet aggregation.
• Vitamin A: High-dose Vitamin E may impair the absorption of Vitamin A.
• Vitamin K: Vitamin E may impair the function of Vitamin K-dependent clotting factors.
• Estrogens: Vitamin E may increase the risk of thrombosis in patients taking oestrogen-containing preparations.
• CYP450-metabolised drugs: Vitamin E undergoes hepatic CYP450 metabolism; caution is advised with enzyme inhibitors or inducers.

Store in a cool, dry place away from direct light and heat. Keep out of reach of children.

What is the price of Biovit-E 200 mg in Bangladesh (BD)?

Biovit-E 200 mg price in Bangladesh is ৳5 per tablet. Prices may vary by pharmacy and are updated regularly on this page.

What is Biovit-E used for?

As a dietary supplement: - Vitamin E deficiency resulting from impaired absorption - Increased requirements due to a diet rich in polyunsaturated fats - Support for healthy hair and skin - As an antioxidant - Hemolytic…

Is Biovit-E an antibiotic?

No, Biovit-E is not an antibiotic.