Bioprem

Biotin is indicated for

• Hair loss
• Weak, brittle, splitting, or soft nails
• Eczema and dermatitis

Take one capsule per day, orally, or as directed by a physician.

Administer orally. Swallow the capsule whole with water, with or without food, once daily or as directed by a physician.

Biotin (Vitamin B7) is a water-soluble B-vitamin that functions as a coenzyme for several carboxylase enzymes involved in energy metabolism. It plays a key role in the carboxylation of acetyl-CoA to malonyl-CoA, the conversion of pyruvate to oxaloacetate, and the conversion of propionyl-CoA to methylmalonyl-CoA — reactions essential for the metabolism of fats, carbohydrates, and amino acids. Biotin also participates in cell signalling and epigenetic regulation through attachment to lysine residues on histones.

Absorption is carrier-mediated via colonic epithelial cells. Biotin is widely protein-bound in the circulation, metabolised in the liver, and excreted by the kidneys. Because it is water-soluble, excess amounts are eliminated in the urine.

Biotin is generally well tolerated. Reported adverse effects are uncommon and may include:

• Upset stomach with excessive intake
• Interference with hormone and thyroid immunoassay results, which may lead to misdiagnosis if laboratory staff are not informed of biotin use

Allergic sensitisation has been reported following oral administration. Consult a physician immediately if any adverse effects occur.

This product is contraindicated in patients with known hypersensitivity to any of its ingredients.

Laboratory test interference: High-dose biotin supplementation can cause clinically significant false results in immunoassay-based tests (e.g. thyroid function, gonadotrophins, vitamin D). Inform the treating physician and laboratory of biotin use before any such tests are performed.

Diabetes: Patients with diabetes should exercise caution, as biotin may influence postprandial glucose control.

Antibiotic use or excessive raw egg white consumption may reduce biotin absorption and precipitate deficiency.

Keep out of reach of children.

Patients with diabetes should use biotin with caution, as it may affect postprandial glucose regulation.

Patients taking anticonvulsants (e.g. carbamazepine, phenobarbital) may have increased biotin requirements due to reduced absorption.

Smokers may require higher biotin intake due to accelerated catabolism.

Pregnancy and lactation increase the body's demand for biotin and may accelerate its metabolism. Biotin should be used during pregnancy or breastfeeding only when clearly needed and after discussion of risks and benefits with a physician.

Biotin is a water-soluble vitamin and excess amounts are excreted in the urine, making significant toxicity unlikely. However, reported symptoms associated with very high intake may include insomnia, excessive thirst, and increased urination. In rare cases, serious adverse events such as eosinophilic pleuropericardial effusion have been documented. No specific antidote exists. In cases of suspected overdose, contact a poison control centre or seek immediate medical attention.

Anticonvulsants (e.g. carbamazepine, phenobarbital) may reduce biotin absorption by inhibiting its membrane uptake, increasing biotin requirements.

Smoking accelerates biotin catabolism; higher intake may be warranted in regular smokers.

Excessive consumption of raw egg whites, which contain the protein avidin, can interfere with biotin absorption and may lead to deficiency.

High-dose biotin supplementation can interfere with certain immunoassay-based laboratory tests — including thyroid function tests, gonadotrophin assays, and vitamin D measurements — producing false-positive or false-negative results. Patients should inform their healthcare provider and laboratory of biotin use before undergoing such tests.

Store in a cool, dry place away from direct sunlight and moisture. Keep out of reach of children and pets.

What is the price of Bioprem 1000 mcg in Bangladesh (BD)?

Bioprem 1000 mcg price in Bangladesh is ৳15 per capsule. Prices may vary by pharmacy and are updated regularly on this page.

What is Bioprem used for?

Biotin is indicated for: - Hair loss - Weak, brittle, splitting, or soft nails - Eczema and dermatitis

Is Bioprem an antibiotic?

No, Bioprem is not an antibiotic.