Evit

As a dietary supplement

• Vitamin E deficiency resulting from impaired absorption
• Increased requirements due to a diet rich in polyunsaturated fats
• Support for healthy hair and skin
• As an antioxidant to protect body cells from oxidative damage
• Hemolytic anemia due to Vitamin E deficiency

Therapeutic use

• Cardiovascular disease
• Heavy metal poisoning
• Hepatotoxin poisoning
• Hemolytic anemia
• Oxygen therapy
• Nutritional deficiency states

Dosing should be guided by a healthcare professional. General reference ranges are as follows:

Adults

Recommended Daily Allowance (RDA): 15 mg once daily. The Tolerable Upper Intake Level (UL) is 1,000 mg per day; doses above this limit should not be exceeded.

Vitamin E deficiency

60–75 units orally once daily.

Postherpetic neuralgia (off-label)

400 units orally two to four times daily.

Cystic fibrosis

40–400 units daily, adjusted by age.

Pregnant women

15 mg per day; upper limit 800–1,000 mg per day depending on age.

Breastfeeding women

19 mg per day; upper limit 800–1,000 mg per day depending on age.

Pediatric patients

6–11 mg per day, with age-specific upper limits ranging from 200 to 800 mg per day.

Swallow capsules whole with a glass of water. Do not crush or chew the capsules. May be taken with or without food; however, taking with a meal containing fat may improve absorption, as Vitamin E is a fat-soluble vitamin.

Alpha Tocopherol Acetate is the ester form of Vitamin E. After oral ingestion, the acetate ester bond is hydrolysed in the intestinal tract — facilitated by pancreatic carboxyl ester hydrolase — to release free alpha-tocopherol, which is then absorbed in the small intestine.

Absorption is dependent on normal fat-absorption processes: biliary and pancreatic secretions are required for solubilisation of Vitamin E in mixed micelles containing bile acids, fatty acids, and monoglycerides. Following absorption, Vitamin E is transported via chylomicrons and distributed to tissues through lipoprotein metabolism. Alpha-tocopherol is the only form of Vitamin E preferentially retained in human plasma.

Vitamin E acts primarily as a lipid-soluble antioxidant, protecting cell membranes and other cellular structures from free radical-mediated oxidative damage. At the cellular level, alpha-tocopherol inhibits protein kinase C and 5-lipoxygenase, activates protein phosphatase 2A and diacylglycerol kinase, and inhibits platelet aggregation, cell proliferation, and monocyte adhesion.

At recommended doses, Vitamin E is generally well tolerated. Side effects are more likely to occur at high or prolonged doses.

Common (particularly at higher doses):

Diarrhoea, abdominal discomfort or cramps, flatulence, nausea, headache, fatigue, blurred vision

• Serious (associated with high-dose or long-term use):
• Increased risk of bleeding and haemorrhagic stroke
• Muscle weakness
• Potential induction of Vitamin K deficiency
• Necrotising enterocolitis in premature infants (with supplemental use)
• Long-term use of 400 units or more daily has been associated with a modest increase in all-cause mortality in some studies

• Known hypersensitivity to Vitamin E (alpha tocopherol acetate) or to any excipient in the formulation

• Discontinue high-dose Vitamin E supplementation at least one month before any planned surgical procedure, as it may increase the risk of perioperative bleeding.
• Use with caution in patients with Vitamin K deficiency, bleeding disorders (e.g. haemophilia, bleeding peptic ulcers), or other conditions predisposing to haemorrhage.
• Patients with cardiovascular disease or diabetes should avoid doses of 400 units per day or more unless directed by a physician, as studies suggest a potential for serious adverse effects at these levels.
• High-dose supplementation should not replace a balanced diet or be used without medical supervision.
• Keep out of reach of children.

Premature and very low birth weight infants

At increased risk of Vitamin E deficiency due to limited placental transfer; supplementation may be required under medical supervision.

Individuals with fat malabsorption disorders

Conditions such as Crohn's disease, cystic fibrosis, and abetalipoproteinaemia impair intestinal absorption of fat-soluble vitamins including Vitamin E. These patients may require supplementation and should be monitored by a healthcare professional.

Elderly patients

No specific dose adjustment is established, but caution is advised with high-dose supplementation given the potential for increased bleeding risk and interaction with cardiovascular medications.

Pregnancy

Vitamin E at Recommended Daily Allowance (RDA) levels (15 mg per day) is considered acceptable during pregnancy, with no evidence of fetal risk demonstrated in controlled studies. Doses above the RDA should not be used during pregnancy without medical supervision, as safety at higher doses has not been established.

Breastfeeding

Vitamin E is excreted in breast milk. Supplementation at the recommended daily intake for lactating women (19 mg per day) is considered safe. Higher doses should only be used on the advice of a healthcare professional.

Vitamin E toxicity does not occur from dietary intake alone. Overuse of supplemental Vitamin E can lead to overdose, which may cause:

• Increased risk of bleeding (especially when taken with anticoagulants)
• Muscle weakness
• Fatigue
• Nausea and diarrhoea

In cases of suspected overdose, discontinue supplementation immediately and seek medical attention or contact a Poison Control Centre. Vitamin K may be administered if bleeding is a concern.

No severe drug interactions have been documented for Vitamin E at recommended doses.

Moderate interactions (use with caution; monitoring may be required)

• Anticoagulants such as warfarin and betrixaban — Vitamin E can potentiate anticoagulant effects and increase bleeding risk, particularly at high doses
• Iron supplements (ferrous sulfate, iron sucrose, polysaccharide-iron complex) — Vitamin E may interfere with iron utilisation
• Vortioxetine, selumetinib, zanubrutinib — potential for additive effects; consult prescribing information

Vitamin E supplementation can induce a functional Vitamin K deficiency, amplifying the risk of bleeding in patients already on anticoagulant therapy. At recommended daily allowance (RDA) levels, clinically significant effects on warfarin are unlikely; however, high-dose supplementation requires careful monitoring.

Store in a cool, dry place, away from direct light and moisture. Keep out of reach of children.

What is the price of Evit 400 mg in Bangladesh (BD)?

Evit 400 mg price in Bangladesh is ৳10 per capsule. Prices may vary by pharmacy and are updated regularly on this page.

What is Evit used for?

As a dietary supplement: - Vitamin E deficiency resulting from impaired absorption - Increased requirements due to a diet rich in polyunsaturated fats - Support for healthy hair and skin - As an antioxidant to protect…

Is Evit an antibiotic?

No, Evit is not an antibiotic.