Cozyme

Cozyme is indicated for the management of Coenzyme Q10 deficiency and mitochondrial disorders. It is also used as an adjunct in the following conditions:

• Congestive heart failure and myocardial infarction
• Hypertension, in combination with other antihypertensive medications
• Prevention of migraine headaches
• Parkinson's disease
• Male infertility
• Muscular dystrophy
• Support of immune system function

Dosage should be individualised according to the indication and the patient's clinical response. Divided daily doses are preferred over a single large dose to improve tolerability and absorption.

Coenzyme Q10 deficiency

150 mg daily.

Mitochondrial disorders

150–160 mg daily, or 2 mg/kg/day.

Congestive heart failure

100 mg daily, in 2 or 3 divided doses.

Myocardial infarction

120 mg daily.

Hypertension

120–200 mg daily.

Migraine prevention

100 mg three times daily.

Parkinson's disease

300–2400 mg daily, in divided doses.

Male infertility

200–300 mg daily.

Muscular dystrophy

100 mg daily.

Coenzyme Q10 capsules should be taken with a meal containing fat, as the lipophilic nature of the compound means absorption is substantially greater when taken with food than on an empty stomach.

The total daily dose should be divided into two or three doses taken throughout the day, rather than taken all at once, to optimise absorption and minimise gastrointestinal side effects.

Coenzyme Q10 (Ubidecarenone) is a fat-soluble, vitamin-like substance naturally present in every cell of the body. It functions as an essential intermediate in the mitochondrial electron transport chain, where it plays a central role in cellular respiration and the production of adenosine triphosphate (ATP).

Tissues with high metabolic activity and energy demands — including the heart, skeletal muscle, liver, kidney, brain, and immune cells — contain the highest concentrations of Coenzyme Q10. Endogenous production of Coenzyme Q10 declines with advancing age.

Because it is a lipophilic compound, absorption is significantly enhanced when taken with a meal containing fat. After absorption, Coenzyme Q10 is incorporated into lipoproteins in the liver and distributed throughout the body. Approximately 60% of an oral dose is eliminated via the feces, with bile as the primary excretion route.

Coenzyme Q10 is generally well tolerated. Adverse effects, when they occur, are typically mild, gastrointestinal in nature, and affect fewer than 1% of patients. They are reversible upon dose reduction or discontinuation.

Gastrointestinal: Nausea, vomiting, diarrhoea, stomach upset, appetite loss, heartburn, and epigastric discomfort.

Dermatological: Allergic skin rashes in susceptible individuals.

Cardiovascular: Dizziness due to lowered blood pressure.

Other: Headache, difficulty sleeping.

Dividing the total daily dose into two or three smaller doses taken throughout the day may reduce the frequency and severity of gastrointestinal side effects.

Coenzyme Q10 is contraindicated in

• Patients with known hypersensitivity to Coenzyme Q10 (Ubidecarenone) or any excipient in the formulation.
• Patients scheduled to undergo surgery within the next two weeks.

Blood glucose: Coenzyme Q10 may lower blood glucose levels. Patients with diabetes or those receiving hypoglycaemic agents should monitor blood glucose and adjust therapy as needed.

Blood pressure: Coenzyme Q10 may lower blood pressure. Patients receiving antihypertensive medications should be counselled about the possibility of an additive blood pressure-lowering effect, and blood pressure should be monitored.

Warfarin therapy: Patients on anticoagulant therapy with warfarin should be monitored, as Coenzyme Q10 may reduce warfarin's effectiveness.

Pre-operative period: Coenzyme Q10 should be discontinued at least two weeks before any planned surgical procedure.

Elderly patients: Endogenous Coenzyme Q10 levels decline with age. Older patients may benefit from supplementation, but should be monitored for blood pressure-lowering effects, particularly if also receiving antihypertensive therapy.

Patients with hepatic impairment: Coenzyme Q10 is incorporated into lipoproteins in the liver and excreted primarily via bile. Use with caution in patients with significant hepatic impairment.

Diabetic patients: Blood glucose should be monitored during therapy, as Coenzyme Q10 may enhance glycaemic control and increase the risk of hypoglycaemia when used alongside antidiabetic medications.

Coenzyme Q10 should not be used during pregnancy or while breastfeeding. The safety of Coenzyme Q10 supplementation in pregnant or lactating women has not been established. Use only if clearly directed by a healthcare professional after careful assessment of potential risks and benefits.

Statins: Statins reduce the body's endogenous synthesis of Coenzyme Q10. Supplementation with Coenzyme Q10 is considered safe and does not interfere with the cholesterol-lowering effect of statins.

Warfarin (anticoagulants): Coenzyme Q10 may diminish the anticoagulant effect of warfarin. Patients on warfarin therapy should be monitored closely.

Beta-blockers: Certain beta-blockers may inhibit Coenzyme Q10-dependent enzymes, potentially reducing its activity.

Antidiabetic medications: Coenzyme Q10 may improve glycemic control and could therefore potentiate the blood glucose-lowering effect of antidiabetic drugs, possibly requiring dose adjustment.

Antihypertensive medications: As Coenzyme Q10 can lower blood pressure, concurrent use with antihypertensive agents may produce an additive effect.

Doxorubicin: Coenzyme Q10 may help mitigate the cardiotoxicity associated with doxorubicin chemotherapy.

Store in a cool, dry place, away from direct light and heat. Keep out of the reach of children.

What is the price of Cozyme 60 mg in Bangladesh (BD)?

Cozyme 60 mg price in Bangladesh is ৳15.05 per capsule. Prices may vary by pharmacy and are updated regularly on this page.

What is Cozyme used for?

Cozyme is indicated for the management of Coenzyme Q10 deficiency and mitochondrial disorders. It is also used as an adjunct in the following conditions: - Congestive heart failure and myocardial infarction -…

Is Cozyme an antibiotic?

No, Cozyme is not an antibiotic.