CoQ

CoQ (Coenzyme Q10 / Ubidecarenone) 60 mg Capsule is indicated for

• Coenzyme Q10 deficiency and mitochondrial disorders
• Congestive heart failure and myocardial infarction (as adjunct therapy)
• High blood pressure (hypertension), used in combination with other medications
• Prevention of migraine headaches
• Parkinson's disease
• Male infertility and female infertility (e.g., poor ovarian reserve, polycystic ovary syndrome)
• Muscular dystrophy
• Supporting immune system function

Dosage should be individualised based on the indication and the patient's clinical response.

Coenzyme Q10 deficiency

The usual dose is 150 mg daily.

Mitochondrial disorders

150–160 mg daily, or 2 mg/kg/day.

Congestive heart failure

100 mg daily, divided into 2 or 3 doses.

Myocardial infarction (adjunct)

120 mg daily in 2 divided doses.

Hypertension

120–200 mg daily.

Migraine prevention

100 mg three times daily.

Male infertility

200–300 mg daily.

Parkinson's disease

300–2400 mg daily in divided doses.

The capsule should be taken with food, preferably with a meal containing fat, to improve absorption.

Take orally with food, preferably with a meal containing fat, to maximise absorption. Swallow the capsule whole with a glass of water.

Coenzyme Q10 (Ubidecarenone) is a fat-soluble, vitamin-like substance that functions as a vital intermediate of the electron transport chain in the inner mitochondrial membrane. It plays an essential role in cellular respiration and the production of adenosine triphosphate (ATP), the primary energy currency of the cell. The highest concentrations of Coenzyme Q10 are found in metabolically active tissues with high energy demands — particularly the heart, liver, kidneys, skeletal muscle, and brain. Endogenous synthesis of Coenzyme Q10 declines naturally with age.

Being lipophilic, absorption from the gastrointestinal tract is significantly enhanced when the capsule is taken with a meal containing fat. After oral administration, Coenzyme Q10 is absorbed from the small intestine into the lymphatic system, subsequently taken up by the liver where it is incorporated into lipoproteins, and then released into the systemic circulation.

Approximately 60% of an oral dose is eliminated via the feces, with biliary excretion as the primary route of elimination.

Coenzyme Q10 is generally well tolerated. Adverse effects are uncommon and typically mild.

• Gastrointestinal (most common):
• Nausea
• Vomiting
• Diarrhoea
• Loss of appetite
• Stomach upset and epigastric discomfort
• Heartburn
• Other reported effects:
• Headache
• Dizziness (associated with blood pressure lowering)
• Difficulty sleeping
• Skin rash (rarely, allergic)

Gastrointestinal effects occur in fewer than 1% of patients and may be reduced by taking the capsule with food.

Coenzyme Q10 is contraindicated in patients with

• Known hypersensitivity to Coenzyme Q10 (Ubidecarenone) or any component of the formulation
• Biliary obstruction
• Severe hepatic insufficiency
• Pre-operative patients scheduled for surgery within two weeks (due to potential effects on blood pressure and blood glucose)

Use with concurrent antihypertensive therapy, cancer chemotherapy, or radiation therapy requires medical supervision.

Diabetes and hypoglycaemia: Coenzyme Q10 may lower blood glucose levels. Patients with diabetes or those at risk of hypoglycaemia should monitor blood glucose carefully and consult their physician before use, as dose adjustment of antidiabetic medication may be needed.

Low blood pressure / antihypertensive therapy: Coenzyme Q10 has mild antihypertensive properties. Caution is warranted in patients with low blood pressure or those already taking antihypertensive medications, as an additive hypotensive effect may occur.

Anticoagulant therapy: Patients on warfarin or other anticoagulants should be monitored closely, as Coenzyme Q10 may reduce anticoagulant efficacy.

Pre-operative use: Coenzyme Q10 should be discontinued at least two weeks before elective surgery.

Hepatic impairment: Use with caution in patients with hepatic insufficiency.

Pregnancy and lactation: Should not be used during pregnancy or breastfeeding (see Pregnancy & Lactation section).

Paediatric use: Safety and dosing in children should be guided by a physician.

Keep out of the reach of children.

Elderly patients: Endogenous Coenzyme Q10 levels decline with age, making elderly patients more likely to benefit from supplementation. No specific dose adjustment is established; clinical response should guide dosing.

Diabetic patients: Monitor blood glucose closely, as Coenzyme Q10 may improve insulin sensitivity and lower blood glucose, potentially requiring adjustment of antidiabetic therapy.

Patients with hypertension: Use with caution alongside antihypertensive medications due to additive blood pressure–lowering effects.

Patients on anticoagulants: Close monitoring of coagulation parameters (e.g., INR) is recommended.

Paediatric patients: Dosing in children should be determined and supervised by a physician.

Hepatic impairment: Use with caution; no specific dose recommendation is established for severe hepatic insufficiency.

Coenzyme Q10 should not be used during pregnancy or while breastfeeding. Consult a physician before use if pregnant, planning to become pregnant, or lactating.

An overdose of Coenzyme Q10 is unlikely to cause serious harm. Very high doses may produce mild gastrointestinal symptoms such as nausea, diarrhoea, and stomach discomfort. If overdose is suspected, supportive care should be provided and a physician consulted.

Warfarin and anticoagulants: Coenzyme Q10 may reduce the anticoagulant effectiveness of warfarin. Patients receiving warfarin should be monitored closely.

Statins (e.g., atorvastatin, fluvastatin): Statins reduce endogenous synthesis of Coenzyme Q10. Supplementation may be considered in such patients without adversely affecting statin efficacy.

Antihypertensive agents: Coenzyme Q10 has mild blood pressure–lowering properties. Concurrent use with antihypertensive drugs may produce an additive effect; blood pressure should be monitored.

Antidiabetic medications: Coenzyme Q10 may improve glycaemic control. When used alongside antidiabetic drugs, blood glucose levels should be monitored and dosage adjustment of the antidiabetic agent may be required.

Beta-blockers: Some beta-blockers may inhibit enzymes that are dependent on Coenzyme Q10.

Doxorubicin: Coenzyme Q10 may reduce the cardiotoxicity associated with doxorubicin chemotherapy.

Store in a cool, dry place away from light and heat. Keep out of the reach of children.

What is the price of CoQ 60 mg in Bangladesh (BD)?

CoQ 60 mg price in Bangladesh is ৳8.02 per capsule. Prices may vary by pharmacy and are updated regularly on this page.

What is CoQ used for?

CoQ (Coenzyme Q10 / Ubidecarenone) 60 mg Capsule is indicated for: - Coenzyme Q10 deficiency and mitochondrial disorders - Congestive heart failure and myocardial infarction (as adjunct therapy) - High blood pressure…

Is CoQ an antibiotic?

No, CoQ is not an antibiotic.