Cardi Q

Coenzyme Q10 (Ubidecarenone) 100 mg capsules are indicated for

• Coenzyme Q10 deficiency and mitochondrial disorders
• Congestive heart failure and myocardial ischemia
• High blood pressure (hypertension), used in combination with other medications
• Prevention of migraine headaches
• Parkinson's disease
• Male infertility and muscular dystrophy
• Supporting immune system function

Dosage should be individualised according to the indication and clinical response. The following doses have been used:

Coenzyme Q10 deficiency

150 mg daily.

Mitochondrial disorders

150–160 mg daily, or 2 mg/kg/day.

Congestive heart failure

100 mg daily, divided into 2 or 3 doses.

Hypertension (adjunctive)

120–200 mg daily, in divided doses.

Migraine prevention

100 mg three times daily.

Parkinson's disease

300–2400 mg daily, in divided doses.

Male infertility

200–300 mg daily.

Dividing the total daily dose into smaller amounts taken two or three times a day may help reduce gastrointestinal side effects.

Capsules should be taken orally with meals, preferably with a fat-containing food, as absorption is significantly enhanced when taken with dietary fat. The total daily dose may be divided into two or three smaller doses taken throughout the day to improve tolerability.

Coenzyme Q10 (Ubidecarenone) is a fat-soluble, vitamin-like substance that acts as an essential intermediate in the mitochondrial electron transport chain, supporting cellular respiration and ATP (energy) production. It also functions as a fat-soluble antioxidant involved in oxidative respiration through the Krebs cycle.

Metabolically active tissues — including the heart, skeletal muscle, brain, and immune system — have the highest requirement for Coenzyme Q10. Endogenous levels decline with age and in a number of disease states.

Absorption and Distribution

Coenzyme Q10 is lipophilic and is absorbed from the small intestine into the lymphatic system. Absorption is significantly greater when taken with a fat-containing meal. After intestinal absorption, it is taken up by the liver, incorporated into lipoproteins, released into the circulation, and distributed to tissues throughout the body, including the brain.

Metabolism and Elimination

Coenzyme Q10 is metabolised in tissues throughout the body. Approximately 60% of an oral dose is eliminated in the faeces, primarily via biliary excretion.

Coenzyme Q10 is generally well tolerated. Gastrointestinal effects, when they occur, affect fewer than 1% of patients and are reversible.

Gastrointestinal: Nausea, vomiting, diarrhoea, stomach upset, appetite loss, heartburn, and epigastric discomfort.

Other: Headache, dizziness, sleep disturbance, and allergic skin rashes.

Cardiovascular: Hypotension (reduced blood pressure) may occur, particularly in patients already on antihypertensive treatment.

Coenzyme Q10 (Ubidecarenone) is contraindicated in

• Patients with known hypersensitivity to Coenzyme Q10 (Ubidecarenone) or to any excipient in the formulation.
• Patients scheduled for surgery within the next two weeks.

• Diabetes: Coenzyme Q10 may lower blood glucose levels. Patients with diabetes or those taking antidiabetic medications should monitor blood sugar closely, as dose adjustment of antidiabetic therapy may be required.
• Hypertension: May cause additive blood pressure lowering when used with antihypertensive drugs; blood pressure should be monitored.
• Anticoagulant therapy: Use with caution in patients on warfarin or other anticoagulants due to potential reduction in anticoagulant effect; close monitoring of clotting parameters is advisable.
• Pre-surgical period: Coenzyme Q10 should be discontinued at least two weeks before any planned surgical procedure.
• Age-related decline: Endogenous Coenzyme Q10 levels decline with age, which may be a consideration in elderly patients.

Elderly patients: Endogenous Coenzyme Q10 levels decline with advancing age, which may increase the relevance of supplementation in this group. No specific dose adjustment is established, but clinical monitoring is advisable.

Patients with diabetes: Coenzyme Q10 may influence blood glucose control; close monitoring is required and antidiabetic drug doses may need to be reviewed.

Patients on anticoagulant therapy: Warfarin effectiveness may be reduced; increased monitoring of anticoagulation status is recommended.

Patients scheduled for surgery: Coenzyme Q10 should be stopped at least two weeks before any elective surgical procedure.

Pregnancy: Safety data in pregnancy are limited. Coenzyme Q10 should generally not be used during pregnancy unless clearly necessary and under medical supervision. If use is being considered, the prescribing physician should be consulted.

Lactation: It is not known whether Coenzyme Q10 is excreted in human breast milk. Use during breastfeeding is not recommended without medical advice.

• Warfarin (anticoagulants): Coenzyme Q10 may reduce the anticoagulant effect of warfarin by enhancing clotting. Patients on warfarin should be monitored closely if Coenzyme Q10 is added or withdrawn.
• Antihypertensive medications: Combined use may cause an excessive reduction in blood pressure. Blood pressure should be monitored when used alongside antihypertensive therapy.
• Antidiabetic medications: Coenzyme Q10 may improve glycaemic control, potentially requiring adjustment of antidiabetic drug doses to avoid hypoglycaemia.
• Statins: Statin therapy may reduce endogenous Coenzyme Q10 synthesis; supplementation may help maintain levels without affecting statin efficacy.
• Beta-blockers: Some beta-blockers may inhibit Coenzyme Q10-dependent enzymes.
• Doxorubicin: Coenzyme Q10 may help reduce the cardiotoxicity associated with doxorubicin chemotherapy.

Store in a cool, dry place, away from direct light and heat. Keep out of the reach of children. Store at room temperature (20–25°C).

What is the price of Cardi Q 100 mg in Bangladesh (BD)?

Cardi Q 100 mg price in Bangladesh is ৳20 per capsule. Prices may vary by pharmacy and are updated regularly on this page.

What is Cardi Q used for?

Coenzyme Q10 (Ubidecarenone) 100 mg capsules are indicated for: - Coenzyme Q10 deficiency and mitochondrial disorders - Congestive heart failure and myocardial ischemia - High blood pressure (hypertension), used in…

Is Cardi Q an antibiotic?

No, Cardi Q is not an antibiotic.