Risperdal Consta

For patients who have never taken oral Risperidone, tolerability should be established with oral Risperidone prior to initiating treatment with Risperidone. Administer by deep intramuscular (IM) deltoid or gluteal injection. Each injection should be administered by a health care professional using the appropriate enclosed safety needle (1-inch for deltoid administration alternating injections between the two arms and 2-inch for gluteal administration alternating injections between the two buttocks). Do not administer intravenously. 25 mg intramuscular (IM) every 2 weeks. Patients not responding to 25 mg may benefit from a higher dose of 37.5 mg or 50 mg. The maximum dose should not exceed 50 mg every 2 weeks. Oral Risperidone (or another antipsychotic medication) should be given with the first injection of Risperidone, and continued for 3 weeks (and then discontinued) to ensure adequate thera peutic plasma concentrations from Risperidone Upward dose adjustment of Risperidone should not be made more frequently than every 4 weeks. Clinical effects of each upward dose adjustment should not be anticipated earlier than 3 weeks after injection. Avoid inadvertent administration into a blood vessel.

The mechanism of action of risperidone in schizophrenia is unclear. The drug’s therapeutic activity in schizophrenia could be mediated through a combination of dopamine Type 2 (D2) and serotonin Type 2 (5HT2) receptor antagonism. The clinical effect from risperidone results from the combined concentrations of risperidone and its major active metabolite, 9-hydroxyrisperidone (paliperidone). Antagonism at receptors other than D2 and 5HT 2 may explain some of the other effects of risperidone

Increased mortality in elderly patients with dementia-related psychosis Cerebrovascular adverse events, including stroke, in elderly patients with dementia-related psychosis Neuroleptic malignant syndrome Tardive dyskinesia Metabolic changes Hyperprolactinemia Orthostatic hypotension Falls Leukopenia/Neutropenia and Agranulocytosis Potential for cognitive and motor impairment Seizures Dysphagia Priapism Thrombotic Thrombocytopenic Purpura (TTP) Disruption of body temperature regulation Avoidance of inadvertent injection into a blood vessel

Known hypersensitivity to risperidone, paliperidone, or to any excipients in Risperidone

Increased Mortality in Elderly Patients with Dementia-Related Psychosis Cerebrovascular Adverse Events, Including Stroke, in Elderly Patients with Dementia-Related Psychosis Neuroleptic Malignant Syndrome Tardive Dyskinesia Hyperprolactinemia Orthostatic Hypotension

Due to CNS effects, use caution when administering with other centrally-acting drugs. Avoid alcohol. Due to hypotensive effects, hypotensive effects of other drugs with this potential may be enhanced. Effects of levodopa and dopamine agonists may be antagonized. Cimetidine and ranitidine increase the bioavailability of risperidone. Clozapine may decrease clearance of risperidone. Fluoxetine and paroxetine increase plasma concentrations of risperidone. Carbamazepine and other enzyme inducers decrease plasma concentrations of risperidone.