Proctil

Adults and Adolescents (13 years and older) Pharyngitis/tonsillitis : 100 mg 12 hourly, 5 to 10 days Acute maxillary sinusitis : 200 mg 12 hourly, 10 day Community acquired pneumonia : 200 mg 12 hourly, 14 days Acute bacterial exacerbations of chronic bronchitis : 200 mg 12 hourly, 10 days Skin and skin structure : 400 mg 12 hourly, 7 to 14 days Uncomplicated urinary tract infection : 100 mg 12 hourly, 7 days Uncomplicated gonorrhea : single dose of 200 mg Rectal gonococcal infections in women: single dose of 200 mg Infants and Pediatric Patients (2 months to 12 years) Acute otitis media : 5 mg/kg body weight 12 hourly, 5 days Pharyngitis /tonsillitis : 5 mg/kg body weight 12 hourly, 5 to 10 days Acute maxillary sinusitis : 5 mg/kg body weight 12 hourly, 10 days

Cefpodoxime is an oral 3rd generation cephalosporin, which has good stability to beta lactamases and activity against Gram negative and Gram positive bacteria. It is indicated for the treatment of infections either before the infecting organism has been identified. It is a prodrug its active metabolite is Cefpodoxime. Approximately 29 to 33% of Cefpodoxime excreted unchanged in the urine in 12 hours.

Cefpodoxime has very few side effects. Possible side effects include gastrointestinal disorders (such as- diarrhea, nausea, vomiting and abdominal pain), rash, urticaria and itching.

Cefpodoxime is contraindicated in patients with known allergy to cephalosporins.

In patients with transient or persistent reduction in urinary output due to renal insufficiency, the total daily dose of Cefpodoxime should be reduced. Cefpodoxime should be administered with caution to patients receiving concurrent treatment with potent diuretics. As with other antibiotics, prolonged use of Cefpodoxime may result in overgrowth of non-susceptible organisms.

Cefpodoxime concomitant administration of high doses of antacids (sodium bicarbonate and aluminum hydroxide) or H2 blockers reduces peak plasma levels and the extent of absorption respectively. Renal excretion of Cefpodoxime is inhibit by probenecid.