Pansos

Pansos is indicated where suppression of acid secretion has therapeutic benefit; i.e

• Peptic ulcer diseases
• Gastroesophageal reflux diseases
• Ulcer induced by non-steroidal anti-inflammatory drugs (NSAIDs)

Eradication of Helicobacter pylori (in combination with antibiotics)

Zollinger-Ellison Syndrome

Oral

Benign gastric ulcer

: 40 mg daily in the morning for 4 weeks, continued for further 4 weeks, if not fully healed.

Gastro-esophageal reflux disease

: 20-40 mg daily in the morning for 4 weeks, continued for further 4 weeks, if not fully healed; maintenance dose is 20 mg daily, which may be increased to 40 mg daily.

Duodenal ulcer

: 40 mg daily in the morning for 2 weeks, continued for further 2 weeks if not fully healed.

Duodenal ulcer associated with Helicobacter pylori

: Pantoprazole is recommended at a dose of 40 mg twice daily in association with antimicrobial agents as detailed below: Amoxycillin 1 g and Clarithromycin 500 mg both twice daily for one week, or Clarithromycin 250 mg and Metronidazole 400 mg both twice daily for one week.

Prophylaxis of NSAID-associated gastric or duodenal ulcer

: 20 mg daily for those require long-term NSAID treatment.

Zollinger-Ellison Syndrome

: Initially 80 mg once daily adjusted according to response (elderly max. 40 mg daily); daily doses above 80 mg given in 2 divided doses.

IV Injection

Duodenal ulcer and gastric ulcer

: 40 mg once daily for 7-10 days

Gastroesophageal reflux disease associated with a history of erosive esophagitis

• : 40 mg once daily for 7-10 days
• Prevention of rebleeding in peptic ulcer
• : IV 80 mg, followed by 8 mg/hour infusion for 72 hours
• Prophylaxis of acid aspiration
• : 80 mg IV every 12 h for 24 h, followed by 40mg every 12 hour

Long-term management of Zollinger-Ellison Syndrome and other pathological hypersecretory conditions

: 80 mg IV every 12 hours, may increase to 80 mg every 8 hours if needed, may titrate to higher doses depending on acid output.

Pantoprazole is a proton pump inhibitor that suppresses the final step in gastric acid production by covalently binding to the H

• /K

ATPase enzyme system at the surface of the gastric parietal cell. This effect leads to inhibition of both basal and stimulated gastric acid secretion, irrespective of the stimulus that persists longer than 24 hours.

Pansos is well tolerated in both short-term and long-term treatment. Headache and diarrhea are the common side effects and rarely included side effects are abdominal pain, flatulence, rash, insomnia and hyperglycemia.

Pantoprazole is contraindicated in patients with known hypersensitivity to any of the components of the formulation.

Patients should be cautioned that Pansos tablet should not be split, chewed or crushed. Long-term therapy of Pansos may lead to malabsorption of cyanocobalamin (Vitamin B12) or may increase the risk of osteoporosis related disorders.

US FDA Pregnancy Category of Pantoprazole is B. There are, however, no adequate and well-controlled studies in pregnant woman. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Pantoprazole has been shown to be excreted in human milk. So, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the benefit of the drug to the mother.

There are no known symptoms of overdosage in humans. Since Pansos is highly protein bound, it is not readily dialyzable. Apart from symptomatic and supportive management, no specific therapy is recommended.

No significant drug interactions have been observed in clinical studies.

Keep in a dry place, away from light and heat. Keep out of the reach of children.

What is Pansos 40 mg EC Tablet?

Pansos 40 mg EC Tablet is a proton pump inhibitor. It suppresses the final step in gastric acid production.  It is used to treat Peptic ulcer diseases, GERD, Ulcer induced by NSAIDs, Eradication of Helicobacter pylori, Zollinger-Ellison Syndrome.

How long do I need to use Pansos 40 mg EC Tablet before I see improvement in my condition?

Pansos 40 mg EC Tablet is to be taken till the time you see an improvement in your health conditions.

At what frequency do I need to use Pansos 40 mg EC Tablet?

Pansos 40 mg EC Tablet should be taken in the dosage as prescribed by the doctor.

Should I use Pansos 40 mg EC Tablet empty stomach, before food or after food?

Pansos 40 mg EC Tablet should be taken prior to the meal, approximately 30 minutes before it, in the prescribed dosage.

What are the instructions for the storage and disposal of Pansos 40 mg EC Tablet?

Pansos 40 mg EC Tablet should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

What are the effects of Pansos 40 mg EC Tablet older adults?

Pansos 40 mg EC Tablet may increase the risk for bone fractures, especially with longer use, higher doses in older adults. Consult your doctor about ways to prevent bone loss/fracture.

How long does it take for Pansos 40 mg EC Tablet to work?

You should start to feel better within 2 to 3 days. It may take up to 4 weeks for this medication to work properly so you may still have some symptoms during this time.

Is Pansos 40 mg EC Tablet safe?

Yes, Pansos 40 mg EC Tablet is relatively safe. It is advised to consult the doctor before consuming Pansos 40 mg EC Tablet.

Does Pansos 40 mg EC Tablet cause weight gain?

In rare cases, the consumption of Pansos 40 mg EC Tablet can cause weight gain. You are advised to consult your doctor for any weight-related concern.

What are the side effects of Pansos 40 mg EC Tablet?

The side effects of Pansos 40 mg EC Tablet aren't that common. Still, people face the following issues sometimes - headache, diarrhea, constipation, and allergic reaction.

Can I take Pansos 40 mg EC Tablet if I am pregnant or breastfeeding?

Though Pansos 40 mg EC Tablet isn’t a serious issue for pregnant or breastfeeding person, it’s advised not to take medicine unless prescribed by your doctor.

What should I do if I miss a dose of Pansos 40 mg EC Tablet?

If you miss a dose of Pansos 40 mg EC Tablet, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and take your next dose at the regular time.