Mydripine

Adult: IV : Bradycardia: 500 mcg every 3-5 mins. Total: 3 mg. IV/IM : Organophosphorus poisoning: 2 mg every 10-30 mins until muscarinic effects disappear or atropine toxicity appears. IM/SC : Premedication in anesthesia: 300-600 mcg 30-60 mins before anesthesia. IV/IM/SC : Poisoning or overdosage with compound having muscarinic actions: 0.6-1 mg, repeat 2 hrly. Ophthalmic : Inflammatory eye disorders: As 0.5-1% solution: 1-2 drops 4 times/day. Ophthalmic : refraction: 1% solution 1 drop twice daily for 1-2 days before procedure. Oral : Non ulcer dyspepsia, Irritable bowel syndrome, Diverticular disease: 0.6-1.2 mg as a single dose at bedtime. Usual Pediatric Dose for Anesthesia: 7 to 16 pounds : 0.1 mg, IV, IM, or subcutaneously 17 to 24 pounds : 0.15 mg, IV, IM, or subcutaneously 24 to 40 pounds : 0.2 mg, IV, IM, or subcutaneously 40 to 65 pounds : 0.3 mg, IV, IM, or subcutaneously 65 to 90 pounds : 0.4 mg, IV, IM, or subcutaneously Over 90 pounds : 0.4 to 0.6 mg, IV, IM, or subcutaneously

Atropine binds to and inhibit muscarinic acetylcholine receptors, producing a wide range of anticholinergic effects. Atropine is an anticholinergic agent which competitively blocks the muscarinic receptors in peripheral tissues such as the heart, intestines, bronchial muscles, iris and secretory glands. Some central stimulation may occur. Atropine abolishes bradycardia and reduces heart block due to vagal activity. Smooth muscles in the bronchi and gut are relaxed while glandular secretions are reduced. It also has mydriatic and cycloplegic effect.

Injection : Dry mouth, dysphagia, constipation, flushing and dryness of skin, tachycardia, palpitations, arrhythmias, mydriasis, photophobia, cycloplegia, raised intraocular pressure. Toxic doses cause tachycardia, hyperpyrexia, restlessness, confusion, excitement, hallucinations, delirium and may progress to circulatory failure and resp depression. Eye drops or ointment : Systemic toxicity esp in children, on prolonged use may lead to irritation, hyperaemia, oedema and conjunctivitis. Increased intraocular pressure.

Glaucoma, chronic respiratory disease, sick sinus syndrome, thyrotoxicosis, cardiac failure, pyloric stenosis, prostatic hypertrophy.

Reflux oesophagitis; elderly; infants and children; Pregnancy.

Additive anticholinergic effects with quinidine, antidepressants and some antihistamines.