Lomir

Adult : Initially, 2.5 mg bid, increase if necessary after 3-4 wk to 5 mg bid, or 10 mg bid as required. Elderly : Initially, 1.25 mg bid. Maintenance: 2.5 or 5 mg once daily. Hepatic Impairment : Initially 1.25 mg bid. Maintenance: 2.5 or 5 mg once daily. May be taken with or without food.

Isradipine is a dihydropyridine Calcium channel blocker. It prevents Ca ++ ions from entering the slow channels or select voltage-sensitive areas of vascular smooth muscle and myocardium during depolarisation, producing a relaxation of coronary vascular smooth muscle and coronary vasodilation.

Headache, dizziness, palpitations, tachycardia, peripheral oedema, flushing, dyspnoea, abdominal discomfort, rash, pruritus, polyuria, fatigue, malaise.

Cardiogenic shock, within 1 mth of MI, unstable angina, treatment of hypertensive crisis.

Patients with CHF, severe aortic stenosis, hypertrophic cardiomyopathy with outflow tract obstruction. Hepatic impairment. Pregnancy and lactation.

Concurrent admin with enzyme-inducing drugs (e.g. rifampicin, phenobarbital, carbamazepine) reduced plasma concentrations of isradipine. Increased bioavailability with cimetidine. May increase serum levels with CYP3A4 inhibitors (e.g. macrolides, HIV protease inhibitors, azole antifungals, delavirdine).