HB-fix

HB-fix is indicated for active immunization against infection caused by all known subtypes of HB-fix B virus. As HB-fix D (caused by the delta virus) does not occur in the absence of HB-fix B infection, it can be expected that HB-fix D will also be prevented by HB-fix B vaccination... Read more

HB-fix is indicated for active immunization against infection caused by all known subtypes of HB-fix B virus. As HB-fix D (caused by the delta virus) does not occur in the absence of HB-fix B infection, it can be expected that HB-fix D will also be prevented by HB-fix B vaccination.

Immunization is recommended in persons of all ages, especially those who are, or will be, at increased risk of exposure to HB-fix B virus, for example:

A baby whose mother is infected can be infected at birth. Children, adolescents, and adults can become infected by:

Contact with blood and body fluids through breaks in the skin such as bites, cuts, or sores

Contact with objects that have blood or body fluids on them such as toothbrushes, razors or monitoring and treatment devices for diabetes

• Having unprotected sex with an infected person
• Sharing needles when injecting drugs
• Being stuck with a used needle
• Household contacts of people infected with HB-fix B
• Residents and staff in institutions for the developmental^ disabled
• Kidney dialysis patients
• People who travel to countries where HB-fix B is common
• People with HIV infection
• Persons with hemophilia, thalassemia, sickle cell anemia, cirrhosis
• Military personnel identified as being at increased risk.
• Morticians and Embalmers.
• Prisoners.
• Users of illicit injectable drugs.

Others: Police, fire department personnel, who render first aid or medical assistance, and any others who, through their work or personal life-style, may be exposed to the HB-fix B virus.

Neonates, infants and children upto 19 years of age: The recommended dose of Hepatitis B vaccine (rDNA) is >10 mcg of antigen protein in 0.5 ml.

Adults 19 years of age and older: The recommended dose of Hepatitis B vaccine (rDNA) is >20 mcg of antigen in 1 ml.

Primary immunization schedule for all ages

The usual immunization schedule consists of 3 doses of vaccine

• First dose: at elected date
• Second dose: 1 month after first dose
• Third dose: 6 months after first dose

or accelerated schedule consists of 4 doses of vaccine

• First dose: at elected date
• Second dose: 1 month after first dose
• Third dose: 2 months after first dose
• Fourth dose: 12 months after first dose

Accelerated schedule confer protection more quickly and is expected to provide better patient compliance.

• Neonate born to hepatitis B surface antigen-positive mother, 4 doses of 10 micrograms:
• First dose: at birth with Hepatitis B immunoglobulin injection (separate site)
• Second dose: 1 month after first dose
• Third dose: 2 months after first dose
• Fourth dose: 12 months after first dose
• For travellers departing within 1 month, adult over 18 years,
• First dose: at elected date
• Second dose: 7 days after first dose
• Third dose: 21 days after first dose
• Fourth dose: 12 months after first dose

Renal insufficiency (including haemodialysis patients), adult and child over 16 years 4 doses of 40 micrograms

• First dose: at the appropriate date
• Second dose: 1 month after first dose
• Third dose: 2 months after first dose
• Fourth dose: 6 months after first dose

Immunization schedule and booster doses may need to be adjusted in those with low antibody concentration.

Booster vaccinations: For persons with normal immune status who have been vaccinated, booster doses of

Hepatitis B vaccine has not been established. However, booster doses are recommended for hemodialysis patients or other immunocompromised persons.

Method of administration: Hepatitis B Vaccine is for intramuscular injection only. Do not inject intravenously. Hepatitis B Vaccine should be given intramuscularly in the deltoid muscle of adult and children or in the anterolateral aspect of thigh in children under 1 year.

Preparation for administration: The vaccine should be shaken well before use to obtain a homogenous turbid white suspension. Do not shake vigorously. The vaccine should be inspected visually for particulate matter and discoloration prior to administration. If either of these conditions exists, the vaccine should not be administered. The vaccine should be used as supplied; no dilution is necessary

Co-administration: Hepatitis B vaccine can be given at the same time with other vaccine as Diphtheria, Tetanus, Pertussis (DTP), Polio (OPV), Measles, Mumps and Rubella (MMR), Haemophilus influenzae b, Hepatitis A and BCG vaccines at separate sites and with separate syringes. It should not be mixed with other vaccines or medicinal products in the same syringe.

HB-fix is generally well tolerated. Most recipients of HB-fix experience some reactions upon vaccination. These are generally moderate and short. They mainly consist of local reactions at the injection site (erythema, induration and tenderness). Systemic reactions (malaise, headache, diarrhea, vomiting, myalgia and elevated temperature) are reported less commonly. In very rare cases allergic type reactions (pruritus, rash, urticaria) may be observed.

Hypersensitivity to any component of the vaccine, including yeast, is a contraindication. This vaccine is contraindicated in patients with previous hypersensitivity to any Hepatitis B virus containing vaccine.

The effect of Hepatitis B on fetal development or reproduction capacity has not been evaluated. However, it should only be used during pregnancy when there is a high risk of infection. Adequate human data on use during lactation and adequate animal reproduction studies are not available. It may be administered to nursing mothers only if clearly needed.

Keep out of the reach and sight of children. Store at +2°C to +8°C. Transportation should also be at +2°C to +8°C. Protect from light. Do not freeze.

What is the price of HB-fix 20 mcg/ml in Bangladesh (BD)?

HB-fix 20 mcg/ml price in Bangladesh is ৳500 per vial. Prices may vary by pharmacy and are updated regularly on this page.

What is HB-fix used for?

HB-fix is indicated for active immunization against infection caused by all known subtypes of HB-fix B virus. As HB-fix D (caused by the delta virus) does not occur in the absence of HB-fix B infection, it can be…

Is HB-fix an antibiotic?

No, HB-fix is not an antibiotic.