Fizi

Fizi is indicated for

Prophylaxis of classic (with aura) or common (without aura) migraine

Symptomatic treatment of vestibular vertigo (due to a diagnosed functional disorder of the vestibular system).

Peripheral Vascular Disease (PVD)

Motion sickness

Refractory epilepsy resistant to conventional antiepileptic therapy.

Migraine Prophylaxis

Starting Dose

10 mg at night in patients less than 65 years of age and 5 mg daily in patients older than 65 years. If, during this treatment depressive, extrapyramidal or other unacceptable symptoms occur, administration should be discontinued. If, after 2 months of this initial treatment, no significant improvement is observed, the patient should be considered a non-responder and administration should be discontinued.

Maintenance Treatment

If a patient is responding satisfactorily and if a maintenance treatment is needed, the dose should be decreased to 5 days treatment at the same daily dose with two successive medicine free days every week. Even if the prophylactic maintenance treatment is successful and well tolerated, it should be interrupted after 6 months and it should be re-initiated only if the patient relapses.

Peripheral Vascular disease

10 mg twice daily, up to 30 mg per day if required.

Vertigo & motion sickness

10-20 mg daily for adults and 5 mg daily for children (> 40 kg).

Epileptic seizure

15-20 mg daily in adults and 5 to 10 mg daily for children as an add-on therapy

Flunarizine is the difluorinated derivative of cinnarizine. It is a selective calcium channel antagonist. By reducing excessive transmembrane influx of calcium Flunarizine prevents cellular calcium overload. It does not interfere with normal cellular calcium homeostasis. Flunarizine also has some antihistaminic and sedative properties. It binds at an affinity of 99% to plasma protein.

Drowsiness and/or fatigue, as well as weight gain and/or increased appetite may occur. The following adverse experiences have been reported during chronic treatment with Fizi: depression, of which female patients with a history of depressive illness may be particularly at risk; extrapyramidal symptoms (such as bradykinesia, rigidity, akathisia, orofacial dyskinesia, tremor), of which elderly patients seem particularly at risk. Infrequently reported adverse reaction are: heartburn; nausea; gastralgia; insomnia; anxiety; galactorrhoea; dry mouth; muscle ache; skin rash.

Hypersensitivity to Flunarizine. Flunarizine is contra-indicated in patients with a history of depressive illness, or with pre-existing symptoms of Parkinson's disease or other extrapyramidal disorders.

Fizi may lead to drowsiness which is aggravated by the simultaneous intake of alcohol or other central nervous system depressants. Patients should be cautioned against driving motor vehicles or performing other potentially hazardous tasks where a loss of mental alertness may lead to accidents. Fizi is not suited for aborting a migraine attack. The possible occurrence of an attack is therefore no reason to increase the dose of Fizi. This treatment may give rise to extrapyramidal and depressive symptoms and reveal Parkinsonism, especially in predisposed patients such as the elderly. Fizi should therefore be used with caution in such patients.

Safety in pregnancy and lactation has not been established.

Galactorrhoea has been reported in few women on oral contraceptives within the first two months of Fizi treatment. Hepatic enzyme inducers such as Carbamazepine and Phenytoin may interact with Fizi by increasing its metabolism. So an increase in dosage of Fizi may be required.

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

What is the price of Fizi 5 mg in Bangladesh (BD)?

Fizi 5 mg price in Bangladesh is ৳4 per tablet (৳200 per strip). Prices may vary by pharmacy and are updated regularly on this page.

What is Fizi used for?

Fizi is indicated for Prophylaxis of classic (with aura) or common (without aura) migraine Symptomatic treatment of vestibular vertigo (due to a diagnosed functional disorder of the vestibular system). Peripheral…

Is Fizi an antibiotic?

No, Fizi is not an antibiotic.