Diflu

Instill 1 drop to be instilled into the affected eye(s) 5 times daily.

Fluconazole is fungistatic in action. It inhibits cytochrome P-450 14-α demethylase in susceptible fungi which leads to accumulation of lanosterol and decreased concentration of ergosterol thereby altering cellular membrane resulting in increased membrane permeability, leakage of essential elements and impaired uptake of precursor molecules to DNA.

This drug is generally well tolerated. Eosinophillia has been reported in some patients.

The drug is contraindicated in patients with hypersensitivity to azoles.

Use of fluconazole may result in overgrowth of non-susceptible strains of candida other than Candida albicans

Fluconazole can alter pharmacokinetics of certain drugs undergoing hepatic metabolism.