Combipen

Add 3 ml of water for injection and shake vigorously. Adults: 4,00,000 units once daily or twice daily. Children: Over 25 kg as for adults; under 25 kg reduce proportionally. In severe cases dose may be doubled. Intramuscular injection is the only route of administration of Procaine Penicillin.

Benzylpenicillin has a bactericidal action against gram-positive bacteria, gram-­negative cocci, some other gram-negative bacteria, spirochetes and actinomycetes. It inhibits final cross-linking stage of peptidoglycan production through binding and inactivation of transpeptidases on the inner surface of the bacterial cell membrane thus inhibiting bacterial cell wall synthesis. It is inhibited by penicillinase and other lactamases. Interferes with cell wall mucopeptide synthesis during active multiplication, resulting in bactericidal activity against susceptible microorganisms.

Allergic reactions may occur but usually resolve on cessation of therapy.

Hypersensitivity to penicillin.

Hypersensitivity to cephalosporins. Renal impairment. CHF. Infant. Elderly.

Potentially hazardous interactions: invitro Penicillin inactivates Amino- glycosides, so that they should not be mixed in infusion fluids.