Axinat

Inhalation/Respiratory- Chronic asthma: Adult: As metered dose aerosol or dry powder inhaler: 50 mcg bid, or up to 100 mcg bid if necessary, in asthma patients with more severe airways obstruction. Child: 4-12 yr 50 mcg bid. Prophylaxis of exercise-induced asthma: Adult: As metered dose aerosol or dry powd inhaler: 50 mcg at least 30 min prior to exercise. Child: ≥4 yr Same as adult dose. Chronic obstructive pulmonary disease: Adult: As metered dose aerosol or dry powder inhaler: 50 mcg bid.

Salmeterol stimulates intracellular adenyl cyclase, the enzyme that catalyses the conversion of ATP to cyclic-3',5'-adenosine monophosphate (cAMP) resulting in relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from mast cells.

Dose related tremor, subjective palpitations and headaches are usually mild and transient. Skin reactions, muscle cramps, non-specific chest pain, local irritation and arthralgia have been reported.

Monotherapy in the treatment of asthma. Treatment of status asthmaticus, other acute episodes of asthma or COPD.

Patient with CV disease, CNS disorders, DM, hyperthyroidism, hypokalaemia, seizure disorders, ketoacidosis. Not intended for the relief of acute bronchospasm. Hepatic impairment. Pregnancy and lactation.

As with all the other beta2-agonists there may be interaction with betablocking agents at the receptor site when given concomitantly. Monoamino Oxidase Inhibitors and Tricyclic Antidepressants : These agent should be used with caution because Salmeterol may be potentiated by these agents.