Axicef Plus

Adolescents and adults (13 years and older)- Pharyngitis/tonsillitis : 250 mg b.i.d. for 5-10 days Acute bacterial maxillary sinusitis : 250 mg b.i.d. for 10 days Acute bacterial exacerbation of chronic bronchitis : 250-500 mg b.i.d. for 10 days Secondary bacterial infections of acute bronchitis : 250-500 mg b.i.d. for 5-10 days Uncomplicated skin and skin structure infections : 250-500 mg b.i.d. for 10 days Uncomplicated urinary tract infections : 250 mg b.i.d. for 7-10 days Uncomplicated Gonorrhoea : 1000 mg b.i.d. Single dose Community acquired pneumonia : 250-500 mg b.i.d. for 5-10 days MDR Typhoid Fever : 500 mg b.i.d. for 10-14 days Early Lyme disease : 500 mg b.i.d. for 20 days Paediatric Patients (3 months to 12 years)- Pharyngitis/Tonsillitis : 20 mg/kg/day b.i.d for 5-10 days Acute otitis media : 30 mg/kg/day b.i.d for 10 days Acute bacterial maxillary sinusitis : 30 mg/kg/day b.i.d for 10 days Impetigo : 30 mg/kg/day b.i.d for 10 days

Cefuroxime is a bactericidal second generation cephalosporin antibiotic which is active against a wide range of Gram-positive and Gram-negative susceptible organisms including many beta-lactamase producing strains. Cefuroxime inhibits bacterial cell wall synthesis by interfering with the transpeptidation process. Clavulanic acid is a naturally derived beta lactamase inhibitor produced by Streptomyces clavuligerus. It has similar structure to beta lactam antibiotics which binds irreversibly to beta-lactamase enzymes and inactivates them. Clavulanic acid gives protection of Cefuroxime from degradation by beta lactamase enzymes and provides a solution for the treatment of bacterial infections caused by beta lactam resistant bacteria.

Generally Cefuroxime-Clavulanic Acid is well tolerated. However, a few side effects like nausea, vomiting, diarrhea, abdominal discomfort or pain may occur. As with other broad-spectrum antibiotics, prolonged administration of Cefuroxime and Clavulanic acid combination may result in overgrowth of nonsusceptible microorganisms. Rarely (<0.2%) renal dysfunction, anaphylaxis, angioedema, pruritis, rash and serum sickness like urticaria may appear.

Cefuroxime-Clavulanic Acid is contraindicated in patients with known allergy to cephalosporin & in patients with Pseudomembranous Colitis.

Cefuroxime should be given with care to patients receiving concurrent treatment with potent diuretics & who has history of colitis.

Concomitant administration of probenecid with Cefuroxime-Clavulanic Acid increases the area under the serum concentration versus time curve by 50%. Drug that reduces gastric acidity may result in a lower bioavailability of Cefuroxime and tend to cancel the effect of postprandial absorption.