Venlafaxine Hydrochloride

Venlafaxine tablets is indicated for the treatment of major depressive disorder. The efficacy of venlafaxine tablets, in the treatment of major depressive disorder was established in 6 week controlled trials of adult outpatients whose diagnoses corresponded most closely to the DSM-III ... Read more Venlafaxine tablets is indicated for the treatment of major depressive disorder. The efficacy of venlafaxine tablets, in the treatment of major depressive disorder was established in 6 week controlled trials of adult outpatients whose diagnoses corresponded most closely to the DSM-III or DSM-III-R category of major depression and in a 4 week controlled trial of inpatients meeting diagnostic criteria for major depression with melancholia A major depressive episode implies a prominent and relatively persistent depressed or dysphoric mood that usually interferes with daily functioning (nearly every day for at least 2 weeks); it should include at least 4 of the following 8 symptoms: change in appetite, change in sleep, psychomotor agitation or retardation, loss of interest in usual activities or decrease in sexual drive, increased fatigue, feelings of guilt or worthlessness, slowed thinking or impaired concentration, and a suicide attempt or suicidal ideation. The efficacy of venlafaxine hydrochloride extended-release capsules in maintaining an antidepressant response for up to 26 weeks following 8 weeks of acute treatment was demonstrated in a placebocontrolled trial. The efficacy of venlafaxine tablets in maintaining an antidepressant response in patients with recurrent depression who had responded and continued to be improved during an initial 26 weeks of treatment and were then followed for a period of up to 52 weeks was demonstrated in a second placebo-controlled trial (see Clinical Trials). Nevertheless, the physician who elects to use venlafaxine tablets / extended-release capsules for extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual patient.

brands

Filter:

Sort:

Brand NameDosage FormCompanyStrengthPrice

◎Venlax

Tablet

General Pharmaceuticals Ltd.

Capsule (Extended Release)

Sun Pharmaceutical (Bangladesh) Ltd.

General Pharmaceuticals Ltd.

75 mg

৳10.07

per tablet

1–3 of 3 brands

Clinical Information

Indications

Veniz XR is a serotonin and norepinephrine reuptake inhibitor (SNRI) indicated for the treatment of: Major Depressive Disorder (MDD) Generalized Anxiety Disorder (GAD) Social Anxiety Disorder (SAD) Panic Disorder (PD)

Pharmacology

The mechanism of the antidepressant action of venlafaxine in humans is believed to be associated with its potentiation of neurotransmitter activity in the CNS. Preclinical studies have shown that venlafaxine and its active metabolite, O-desmethylvenlafaxine (ODV), are potent inhibitors of neuronal serotonin and norepinephrine reuptake and weak inhibitors of dopamine reuptake. Venlafaxine and ODV have no significant affinity for muscarinic, histaminergic, or α-1 adrenergic receptors in vitro. Pharmacologic activity at these receptors is hypothesized to be associated with the various anticholinergic, sedative, and cardiovascular effects seen with other psychotropic drugs. Venlafaxine and ODV do not possess monoamine oxidase (MAO) inhibitory activity.

Dosage & Administration

Depression : Initially 75 mg daily in 2 divided doses. Can be increased if necessary after several weeks to 150 mgdaily in 2 divided doses. Severely depressed or hospitalized patients : Initially 150 mg daily in 2 divided doses. Can be increased if necessary in steps of up to 75 mg every 2-3 days to max. 376 mg daily then gradually reduced. Generalised anxiety disorder : 75 mg daily as a single dose.

Side Effects

Side effects that have been most frequently reported withe Veniz XR include nausea, headache, insomnia, dry mouth, dizziness, constipation, sweating, nervousness, asthenia. Orthostatic has been seen occasionally. Other side effects reported include anorexia, dyspepsia, abdominal pain, anxiety sexual dysfunction, visual disturbaces, vasodilatation, vomiting, tremor, chills palpitations, agitation, rashes, convulsion, hypertension.

⚕

Always consult a registered doctor before taking any medicine. This information is for general knowledge only.

Venlafaxine Hydrochloride

Clinical Information

Indications

Pharmacology

Dosage & Administration

Side Effects

Contraindications

Drug Interactions

Precautions & Warnings