Tioconazole

Conasyd is indicated for the local treatment of- Fungal infections of skin: Dermatophyte infections including tinea corporis, tinea cruris, tinea manuum, tinea pedis, pityriasis versicolor (tinea versicolor), dermal candidiasis. Erythrasma: Its activity against some Gram-positive bacteria is an added benefit in mixed infections. Vulvovaginal candidiasis (VVC).

Tioconazole is a topical antifungal agent. It is a broad-spectrum antifungal agent that inhibits the growth of human pathogenic yeasts. It exhibits fungicidal activity in-vitro against Candida albicans, other species of the genus Candida and against Torulopsis glabrata.

Ointment : Tioconazole has been found to be effective as a single-dose treatment for vulvovaginal candidiasis. Insert one applicator-full (about 4.6 g) intravaginally. Administration of Tioconazole just prior to bedtime may be preferred. Cream : Treatment may be once or twice daily in the morning and/or evening. Up to 6 weeks may be required for chronic hyperkeratotic tinea pedis. Suppository : One 300 mg suppository intravaginally as a single dose, preferably at bedtime; for patients who are improved but not completely cured a repeat application may be effective if administered one week later.

Burning and itching were the most frequent side effects occurring in approximately 6% and 5% of the patients respectively. There were occasional reports (less than 1%) of other side effects including irritation, discharge, vulvar edema and swelling, vaginal pain, dysuria, nocturia, dyspareunia, dryness of vaginal secretions, desquamation.