Talaparib is a poly (ADP-ribose) polymerase (PARP) inhibitor indicated for: BRCA-mutated (gBRCAm) HER2-negative Locally Advanced or Metastatic Breast Cancer : As a single agent, for the treatment of adult patients with deleterious or suspected deleterious germline BRCA-mutated ... Read more Talaparib is a poly (ADP-ribose) polymerase (PARP) inhibitor indicated for: BRCA-mutated (gBRCAm) HER2-negative Locally Advanced or Metastatic Breast Cancer : As a single agent, for the treatment of adult patients with deleterious or suspected deleterious germline BRCA-mutated (gBRCAm) HER2-negative locally advanced or metastatic breast cancer. HRR Gene-mutated mCRPC : In combination with Enzalutamide for the treatment of adult patients with HRR gene-mutated metastatic castration-resistant prostate cancer (mCRPC).
Talazoparib is an inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, including PARP1 and PARP2, which play a role in DNA repair. In vitro studies with cancer cell lines that harbored defects in DNA repair genes, including BRCA1 and BRCA2, have shown that Talazoparib-induced cytotoxicity may involve inhibition of PARP enzymatic activity and increased formation of PARP-DNA complexes resulting in DNA damage, decreased cell proliferation, and apoptosis. Talazoparib anti-tumor activity was observed in patient-derived xenograft breast cancer models bearing mutated BRCA1 or mutated BRCA2 or wild type BRCA1 and BRCA2.
gBRCAm HER2-negative Locally Advanced or Metastatic Breast Cancer: For the treatment of advanced breast cancer with Talazoparib, patients should be selected based on the presence of germline BRCA mutations. HRR Gene-mutated Metastatic Castration-Resistant Prostate Cance r: For the treatment of HRR gene-mutated mCRPC with Talazoparib, patients should be selected based on the presence of HRR gene mutations (ATM, ATR, BRCA1, BRCA2, CDK12, CHEK2, FANCA, MLH1, MRE11A, NBN, PALB2, or RAD51C). Recommended Dosage for gBRCAm HER2-negative Locally Advanced or Metastatic Breast Cancer : The recommended dosage of Talazoparib is 1 mg taken orally once daily until disease progression or unacceptable toxicity. For adverse reactions, dosing interruption or dose reduction should be considered. Recommended Dosage for HRR Gene-mutated mCRPC : The recommended dosage of Talazoparib is 0.5 mg taken orally once daily in combination with Enzalutamide until disease progression or unacceptable toxicity. Talazoparib should be taken with or without food. Talazoparib capsules should be swallowed whole. It should not be opened or dissolved. If a patient vomits or misses a dose of Talazoparib, they should be instructed to take the next prescribed dose at the usual time.
Always consult a registered doctor before taking any medicine. This information is for general knowledge only.
Most common adverse reactions (>20%) as a single agent, including laboratory abnormalities, are: Hemoglobin decreased, neutrophils decreased, lymphocytes decreased, platelets decreased, fatigue, glucose increased, aspartate aminotransferase increased, alkaline phosphatase increased, alanine aminotransferase increased, calcium decreased, nausea, headache, vomiting, alopecia, diarrhea, and decreased appetite.
Breast Cancer : Coadministration of Talaparib should be avoided with the following P-gp inhibitors: itraconazole, amiodarone, carvedilol, clarithromycin, itraconazole, and verapamil. If coadministration of Talaparib with these P-gp inhibitors cannot be avoided, the dose of Talaparib should be reduced. When the P-gp inhibitor is discontinued, the dose of Talaparib should be increased. Coadministration of Talaparib with these P-gp inhibitors increased Talaparib concentrations, which may increase the risk of adverse reactions. Increased adverse reactions should be monitored and the dosage should be modified as recommended for adverse reactions when Talaparib is coadministered with other P-gp inhibitors. HRR Gene-mutated mCRPC : The effect of coadministration of P-gp inhibitors on Talaparib exposure when Talaparib is taken in combination with Enzalutamide has not been studied. Increased adverse reactions should be monitored and the dosage should be modified as recommended for adverse reactions when Talaparib is coadministered with a P-gp inhibitor. Effect of BCRP Inhibitors : Increased adverse reactions should be monitored and the dosage should be modified as recommended for adverse reactions when Talaparib is coadministered with a BCRP inhibitor. Coadministration of Talaparib with BCRP inhibitors may increase Talaparib exposure, which may increase the risk of adverse reactions.
Myelodysplastic Syndrome/Acute Myeloid Leukemia : Myelodysplastic Syndrome/Acute Myeloid Leukemia (MDS/AML), including cases with a fatal outcome, has been reported in patients who received Talaparib. If MDS/AML is confirmed, discontinue Talaparib. Myelosuppression : Myelosuppression consisting of anemia, neutropenia, and/or thrombocytopenia, have been reported in patients treated with Talaparib. If hematological toxicities do not resolve within 28 days, discontinue Talaparib and refer the patient to a hematologist for further investigations including bone marrow analysis and blood sample for cytogenetics. Embryo-Fetal Toxicity : Based on its mechanism of action and findings from animal data, Talaparib can cause fetal harm when administered to a pregnant woman. Infertility : Based on animal studies, Talaparib may impair fertility in males of reproductive potential.