Eptase is indicated for: Systemic administration- acute transmural myocardial infarction (not older than 12 hours), with persistent ST-segment elevation or recent left bundle-branch block deep vein thromboses (not older than 14 days) acute massive pulmonary embolism ... Read more Eptase is indicated for: Systemic administration- acute transmural myocardial infarction (not older than 12 hours), with persistent ST-segment elevation or recent left bundle-branch block deep vein thromboses (not older than 14 days) acute massive pulmonary embolism acute and subacute thromboses of peripheral arteries chronic occlusive arterial diseases (not older than 6 weeks) occlusion of central retinal artery or vein (arterial occlusions not older than 6 to 8 hours, venous occlusions not older than 10 days). Local administration- acute myocardial infarction for re-opening of coronary vessels (not older than 12 hours) acute, subacute and chronic thromboses as well as embolisms of peripheral venous and arterial vessels.
Streptokinase acts with plasminogen to produce an activator complex that converts plasminogen to plasmin. Plasmin degrades fibrin clots as well as fibrinogen and other plasma proteins. Unlike other plasminogen activators, Streptokinase is not an enzyme and does not directly convert plasminogen to plasmin. Instead, Streptokinase forms a 1:1 stoichiometric complex with plasminogen. Formation of this complex induces a conformational change in plasminogen that exposes its active site. This conformationally altered plasminogen then converts additional plasminogen molecules to plasmin. Pharmacokinetics: Plasma Streptokinase concentrations reach a peak at 2 to 3 min after intravenous administration and peak fibrinolytic activity occurs at approximately 30 min depending on the dose. Streptokinase is cleared from the plasma in two phases. The first phase has an average half life of 18 min, and is caused by the presence of antistreptokinase antibody which combines with Streptokinase to produce a complex that is cleared rapidly from the circulation. The second phase is slower, with a half life of approximately 80 min, and reflects the rate at which Streptokinase combines with plasminogen. Hence, the clearance rate will vary according to the availability of plasminogen and the dosage regimen used.
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Acute evolving transmural MI : Administer as soon as possible after symptom onset. The greatest benefit in mortality reduction was observed when Streptokinase was administered within 4 hours, but statistically significant benefit has been reported up to 24 hours. IV infusion- Administer a total dose of 1500000 IU within 60 minutes. Intracoronary infusion- Administer 20000 IU by bolus followed by 2000 IU/min for 60 minutes for a total dose of 140000 IU. PE, DVT, arterial thrombosis, or embolism : Institute treatment as soon as possible after thrombotic event onset, preferably within 7 days. Any delay in instituting lytic therapy to evaluate the effect of heparin therapy decreases the potential for optimal efficacy. Because human exposure to streptococci is common, antibodies to Streptokinase are prevalent. Thus, a loading dose of Streptokinase sufficient to neutralize these antibodies is required. A dose of 250000 IU Streptokinase infused into a peripheral vein over 30 minutes was appropriate in over 90% of patients. If the thrombin time, or any other parameter of lysis after 4 hours of therapy is not significantly different from the normal control level, discontinue Streptokinase because excessive resistance is present. AV cannulae occlusion : Before using, try to clear the cannula by syringe technique, using heparinized saline solution. If adequate flow is not re-established, use Streptokinase. Allow the effect of any pretreatment anticoagulants to diminish. Slowly instill 250000 IU in 2 mL solution into each occluded limb of the cannula. Clamp off cannula limb(s) for 2 hours. Observe closely for adverse effects. After treatment, aspirate contents of infused cannula limb(s), flush with saline, and reconnect cannula. Pediatric use : Controlled clinical studies have not been conducted in children to determine safety and efficacy. The evidence of clinical benefits and risks is solely based on anecdotal reports in patients ranging in age from less than 1 month to 16 years. The largest number of patient reports has pertained to the use of Streptokinase in arterial occlusions. For arterial occlusions, the most frequently used loading dose was 1000 IU/kg; fewer numbers of patients received 3000 IU/kg. Loading dose durations typically have ranged from 5 to 30 minutes. Continuous infusion doses were frequently 1000 IU/kg/h; fewer were at 1500 IU/kg/h. Infusions were maintained for 12 hours or less in approximately half of the published cases; a smaller proportion were between 12 and 24 hours. Reported adverse events associated with the use of Streptokinase in the pediatric population are similar in nature to those associated with its use in adults. Rates of all bleeding complications have been variable and as high as 50% at catheter sites in some studies. Occasionally, bleeding has required transfusion. Careful monitoring of patient status is necessary.
Potentially life-threatening effects : The unwanted effects of Eptase therapy fall into two categories: those resulting from bleeding and those resulting from allergy. Hypotension and arrhythmias may occur in patients with myocardial infarction. Bleeding : Major, life-threatening hemorrhage occurs in 0.2-0.3% of patients. Less severe bleeding has been reported in about 10% of patients. In the event of serious hemorrhage, Eptase therapy should be stopped. Antifibrinolytic therapy (tranexamic acid, aminocaproic acid, or aprotinin) should be considered if there is evidence of persistent fibrinolytic activity in the blood. Transfusions of blood (preferably fresh), cryoprecipitate, or fresh frozen plasma may be necessary. There may also be an excess incidence of cerebral hemorrhage (perhaps 2 per 1000) in patients treated with systemic thrombolytic agents, but there does not appear to be an increase in total strokes- perhaps because of a reduction in ischemic strokes. Allergic reactions : The incidence of allergic reactions appears to have fallen with the introduction of more highly purified forms of Eptase. The incidence of anaphylactic shock is 0.1%. Severe allergic reactions, including death, have been reported in patients with no history of previous exposure to Eptase. Less severe allergic phenomena. such as chills, rigors, nausea, vomiting, and high fever, have been reported in between 2 and 20% of patients. The immunological basis of allergic reactions to Eptase is not entirely clear. Investigation of patients who have suffered allergic reactions have demonstrated low titers of antiEptase IgG and IgG1. There was no evidence of any other 1gG subclass nor of specific antiEptase IgE. There is also evidence of cell-mediated immunity with at least five antigenic epitopes on the Eptase molecule which are recognized by human CD4+T-cell receptor αβ+T cells. Allergic reactions usually respond well to withdrawal of therapy, intravenous hydrocortisone and antihistamines. Although some authorities recommend the use of prophylactic intravenous hydrocortisone, there is no good evidence that this is of value. Acute overdosage : In view of the mode of use of Eptase overdosage is very unlikely and has not been reported. It would lead to hemorrhage.
Contraindications- Bleeding diathesis or active internal bleeding Recent trauma (e.g. head injury. resuscitation) Severe uncontrollable hypertension Stroke or recent cerebrovascular accident Intracranial or intraspinal surgery Known intracranial neoplasm Severe uncontrollable hypertension Uncontrollable clotting disorders Known allergy to Streptokinase Relative contraindications- All forms of reduced blood coagulability, in particular spontaneous fibrinolysis Local lesions with risk of bleeding Recent surgery Recent abortion or delivery Diseases of the urogenital tract with existing or potential sources of bleeding Recent streptococcal infections which have produced high antistreptokinase titers Streptokinase therapy more than 5 days and less than 12 months previously Subacute bacterial endocarditis Pericarditis Severe hypertension or hypertensive retinal changes grades III/IV Disorders of cerebral blood flow or recent cerebral hemorrhage Pulmonary diseases with cavitation or severe bronchitis Acute pancreatitis Advanced age with suspicion of arteriosclerotic degeneration Septic thromboembolic disease.
Potentially hazardous interactions : Early administration of Heparin or Hirudin therapy may increase the risk of hemorrhage. Systemic fibrinogenolysis, which inevitably occurs during Eptase therapy, impairs coagulation both by causing fibrinogen depletion and through the anti-thrombin effects of fibrin degradation products. This may help protect recanalized vessels from reocclusion and may explain the lack of additional benefit from Heparin. Conversely, early Heparin or Hirudin therapy may increase the risk of hemorrhage. Radiological contrast agents : Some radiological contrast agents such as Diatrizoate and Iohexol, but not ioxaglate, are inhibitors of fibrinolysis by Eptase and this may be clinically important. Potentially useful interactions: Antiplatelet therapy : Low-dose aspirin enhances survival in myocardial infarct patients receiving Eptase, without increasing the risk of major hemorrhage. Data are presently inadequate to assess the interaction of Eptase with more powerful inhibitors of platelet function.
High Risk Patients : Carefully evaluate each patient being considered for therapy and weigh anticipated benefits against potential risks associated with therapy. In the following conditions, the risk of therapy may be increased and should be weighed against the anticipated benefits: Recent (within 10 days) major surgery (eg, obstetrical delivery, organ biopsy, previous puncture of noncompressible vessels) Recent (within 10 days) serious gastrointestinal bleeding Recent (within 10 days) trauma including cardiopulmonary resuscitation Hypertension (systolic BP more than 180 mm Hg and/or diastolic BP more than 110 mm Hg) Likelihood of left heart thrombus (eg, mitral stenosis with atrial fibrillation) Subacute bacterial endocarditis Cerebrovascular disease Hemostatic defects including secondary to severe hepatic or renal disease Pregnancy Age over 75 years Diabetic hemorrhagic retinopathy Septic thrombophlebitis or occluded AV cannula at a seriously infected site Any other condition in which bleeding constitutes a significant hazard or would be particularly difficult to manage because of its location Arrhythmias : Rapid lysis of coronary thrombi has been shown to cause reperfusion atrial or ventricular dysrhythmias requiring immediate treatment. Carefully monitor for arrhythmias during and immediately following administration of Eptase for AMI. Occasionally, tachycardia and bradycardia have been observed. Hypotension : Sometimes severe hypotension, not secondary to bleeding or anaphylaxis, may occur during or soon after IV Eptase (1% to 10%). Closely monitor patients and, if symptomatic or alarming hypotension occurs, administer appropriate treatment. This may include a decrease in the IV Eptase infusion rate. Smaller hypotensive effects are common and have not required treatment. Injection sites : If an arterial puncture is necessary, upper extremity vessels are preferable. Apply pressure for at least 30 minutes. Apply a pressure dressing and check puncture site frequently. Respiratory : There have been reports of respiratory depression in patients receiving Eptase. In some cases, it was not possible to determine whether the respiratory depression was associated with Eptase or was a symptom of the underlying process. If respiratory depression is associated with Eptase, the occurrence is believed to be rare. Noncardiogenic pulmonary edema : Noncardiogenic pulmonary edema has been reported rarely in patients treated with Eptase. The risk of this appears greatest in patients who have large MIs undergoing thrombolytic therapy by the intracoronary route. Polyneuropathy : Rarely polyneuropathy has been temporally related to the use of Eptase, with some cases described as Gaillain-Barre syndrome. Anticoagulant and antiplatelets after treatment for MI : In the treatment of AMI, aspirin has been shown to reduce the incidence of reinfarction and stroke. The addition of aspirin to Eptase causes a minimal increase in the risk of minor bleeding (3.9% vs 3.1%) but does not appear to increase the incidence of major bleeding. In the treatment of AMI, aspirin, when not otherwise contraindicated, should be administered with Eptase. The use of anticoagulants following Eptase administration increases the risk of bleeding but has not been shown to be of unequivocal clinical benefit. Therefore, whereas the use of aspirin is recommended unless otherwise contraindicated, the use of anticoagulants should be decided by the treating physician. Anticoagulation after IV treatment for other indications : Continuous IV infusion of heparin, without a loading dose, has been recommended following termination of Eptase, infusion for treatment of PE or DVT to prevent rethrombosis. The effect of Eptase on thrombin time (TT) and activated partial thromboplastin time (aPTT) usually will diminish within 3 to 4 hours after Eptase therapy. Heparin therapy without a loading dose can be initiated when the TT or the aPTT is less than twice the normal control value for Eptase. Cholesterol embolism : Cholesterol embolism has occurred rarely in patients treated with all types of thrombolytic agents; the true incidence is unknown. This serious condition, which can be lethal, is also associated with invasive vascular procedures (eg, cardiac catheterization, angiography, vascular surgery) and/or anticoagulant therapy. Clinical features of cholesterol embolism include livedo reticularis, "purple toe" syndrome, acute renal failure, gangrenous digits, hypertension, pancreatitis, Ml, cerebral infarction, spinal cord infarction, retinal artery occlusion, bowel infarction, and rhabdomyolysis. PE : If PE or recurrent PE occur during Eptase therapy, complete the planned course of treatment in an attempt to lyse the embolus. While PE may occasionally occur during Eptase treatment, the incidence is no greater than when patients are treated with heparin alone. In addition to PE, embolization to other sites during Eptase treatment has been observed. Hypersensitivity reactions : Anaphylactic and anaphylactoid reactions ranging in severity from minor breathing difficulty to bronchospasm, periorbital swelling, or angioneurotic edema have been observed rarely in patients treated with IV Eptase. Fever and shivering, occurring in 1% to 4% of patients, are the most commonly reported allergic reactions with IV Eptase in AMI. Other milder allergic effects, such as urticaria, itching, flushing, nausea, headache, and musculoskeletal pain, have been observed, as have delayed hypersensitivity reactions such as vasculitis and interstitial nephritis.