Sitaquin is indicated for bacterial infections like laryngopharyngitis, tonsillitis, acute bronchitis, pneumonia, and secondary infection of chronic respiratory diseases; Cystitis, pyelonephritis, and urethritis; cervicitis; otitis media and sinusitis; periodontitis, pericoronitis, and osteitis of jaw.
Sitafloxacin has a broad spectrum of antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. The mechanism of action of Sitafloxacin involves inhibition of bacterial DNA gyrase and topoisomerase IV. Bactericidal activity of Sitafloxacin results from inhibition of these enzymes. The inhibitory activity of Sitafloxacin against these enzymes was higher than that of the other quinolone antimicrobials used as comparators. Sitafloxacin also has a potent inhibitory activity against enzymes from quinolone-resistant bacteria.
Recommended Dose: 50 mg twice daily or 100 mg once daily for all indications: Laryngopharyngitis, acute bronchitis & tonsillitis: 3-7 days Pneumonia and secondary infections of chronic respiratory diseases: 7 days Acute cystitis: 3 days Acute pyelonephritis & complicated urinary tract infection: 7-14 days Urethritis and cervicitis: 7 days Acute otitis media and sinusitis: 7 days Acute exacerbation of chronic otitis media and sinusitis: 7 days Periodontitis, pericoronitis and osteitis of jaw: 3-7 days For patients suspected of having a poor response to the usual dosage, a dosage of Sitafloxacin 50 mg tablet may be increased to 100 mg, administered orally twice daily. Not for use by children under 18 years. Renal & Hepatic Impaired Patients : Careful administration should be taken with renal & hepatic impairment patients and if any abnormal symptoms occur, it should be discontinued and appropriate measure should be taken.
Always consult a registered doctor before taking any medicine. This information is for general knowledge only.
Most commonly reported adverse reactions include rash, dizziness, headache, diarrhea, loose stool, stomach discomfort, abdominal bloating, abdominal pain, constipation, indigestion, nausea and stomatitis. If any of these symptoms occur, consult with your doctor or pharmacist.
It is contraindicated in the following patients : Patients with a history of hypersensitivity to any ingredients of Sitafloxacin or other quinolones. Pediatric patients : The safety of Sitafloxacin in low-birth-weight infants, newborn infants, infants and toddlers, children and adolescents has not been established.
Sitaquin should be co-administered with care when administered with the following drugs. Antacids containing aluminum, magnesium, NSAIDs containing phenylacetic acid e.g., Ketoprofen, drugs containing calcium, iron.
Sitaquin should be used with caution in patients with convulsive diseases such as epilepsy or with a history of convulsive diseases, patients with myasthenia gravis, patients complicated with aortic aneurysm or aortic dissection, or patients who have a previous history, positive family history, or risk factors of aortic aneurysm or aortic dissection., elderly patients generally have reduced physiological function.