D-Zole is indicated in- Intestinal Amoebiasis Hepatic Amoebiasis Urethritis and vaginitis due to Trichomonas vaginalis Giardiasis
Secnidazole is rapidly absorbed following oral administration. The maximum serum level is obtained after 3 hours following oral administration of 2 gm Secnidazole. The plasma elimination half-life is about 20 hours. The majority of Secnidazole is eliminated via urine (50% of the ingested dose is excreted within 120 hours). The pharmacokinetic profile of Secnidazole gives it the longest half-life of second-generation nitroimidazoles, ensuring 72-hour therapeutic blood levels from a 2 gm single dose.
Secnidazole tablet should be administered orally. The dosage schedule of is mentioned below: Acute Intestinal Amoebiasis: Adults : 2 gm single dose, taken preferably just before meal. Children : 30 mg/kg single dose, taken preferably just before meal. Asymptomatic Amoebiasis (minute& cystic form): Adults : 2 gm once daily for only 3 days, taken preferably just before meal. Children : 30 mg/kg once daily for only 3 days, taken preferably just before meal. Hepatic Amoebiasis: Evacuation of pus must be performed simultaneously with Secnidazole treatment at the suppurative stage of hepatic amoebiasis. Adults : 1.50 gm/day in a single or divided doses, just before meal, for 5 days. Children : 30 mg/kg/day, in a single or divided dose, just before meal, for 5 days. Giardiasis: Adults : 2 gm single dose, taken preferably just before meal. Children : 35-50 mg/kg single dose, taken preferably just before meal. Trichomoniasis: Adults : 2 gm single dose, taken preferably just before meal. The partner should also receive the same treatment concomitantly.
Always consult a registered doctor before taking any medicine. This information is for general knowledge only.
The clinical studies have shown that D-Zole is characterized by very good tolerance and no serious adverse reactions have been reported to date. The following side-effects may be observed with D-Zole as with all nitroimidazole derivatives & are rarely serious: Most frequent side-effects : Gastrointestinal disturbances, nausea, epigastric pain, metallic taste, glossitis, stomatitis. Occasional side effects : Urticaria, moderate leukopenia which is reversible on treatment discontinuation. Rare side-effects : Vertigo, ataxia and motor incoordination, paresthesia, peripheral neuropathy. With D-Zole, gastrointestinal disorders e.g. nausea, vomiting, eoigastric pain, etc., have been reported in very rare cases.
Secnidazole is contra-indicated for those patients who are hypersensitive to imidazole derivatives.
Administration of D-Zole with disulfiram is not recommended: confusional state & paranoid reaction may occur. Use of D-Zole simultaneously with warfarin requires close monitoring: increased effect or oral anticoagulants and of the hemormagic risk is likely.
Patients should be advised not to take alcohol during treatment with D-Zole (because of the possibility of antabuse effect). Administration of D-Zoleshould be avoided to patients with a history of blood dyscrasia.