Prokind is indicated in the treatment of- Adjunctive therapy in the treatment of peptic ulcer (gastric and duodenal) Relief of the symptoms of gastritis (stomach upset, gastrointestinal bleeding, blood in vomit, blood in stool, persistent pain) Symptomatic treatment of the diarrhoea related irritable bowel syndrome (irritable colon, spastic colon, acute enterocolitis, functional Gl disorders etc) Urinary incontinence Control of salivation and enuresis Improves lactose intolerance Prevents excessive sweating (Hyperhidrosis)
Propantheline Bromide acts by dual mechanism of action. Specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites Direct effect upon smooth muscle (musculotropic). This medication is a muscarinic antagonist having antispasmodic properties. It reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle. It also has a direct relaxing effect on smooth muscle. In addition, Propantheline inhibits gastrointestinal motility and decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretions. Other secretions like pancreatic juice, sweat and saliva are also reduced.
The usual initial adult dose of Propantheline Bromide is 75 mg daily. One tablet 30 min before each meal (15 mg three times daily). Two tablets at bedtime Dosage adjustment should be made according to the patient's individual response and tolerance. But the maximum daily dosage should not exceed 120 mg. Pediatric use: Safety and effectiveness in pediatric patients have not been established.
Always consult a registered doctor before taking any medicine. This information is for general knowledge only.
The adverse effects of Prokind are usually dose-related and are usually reversible when the therapy is discontinued. Variable degrees of dry mouth, dry skin, mydriasis might be noted. Other reported adverse effects include urinary retention, nausea, vomiting, constipation, headache, nervousness, mental confusion etc.
Propantheline Bromide is contraindicated in patients with- Hypersensitivity to Propantheline bromide or other anticholinergic agents; Glaucoma; Obstructive disease of the gastrointestinal tract (pyloroduodenal stenosis, paralytic ileus etc.); Obstructive uropathy (e.g. prostatic hypertrophy) intestinal atony of elderly; Myasthenia gravis.
Antacids or Absorbent Antidiarrhoeals may reduce the absorption of Prokind, therefore resulting in a reduction of its therapeutic effectiveness. Therefore, take two to three hours apart from doses of Prokind. Anticholinergics may delay absorption of other medication given concomitantly. Significant drug interaction also occurs with concomitant use of digoxin, haloperidol, corticosteroides, ketoconazole, levodopa, opioid analgesics, phenothiazines, urinary alkalizers.
Prokind should be used with caution in the elderly and in all patients with autonomic neuropathy, hepatic or renal disease, hyperthyroidism, coronary heart disease, congestive heart failure, cardiac tachyarrhythmias, hypertension, since anticholinergics may aggravate this condition.