Arromin is indicated in- Potent long-acting antihistamine with additional anti-emetic and sedative/calming effects. Indicated in symptomatic treatment of allergic conditions of the respiratory tract and skin. Sensitization reactions to drug or foreign proteins, anaphylactic reactions. For sedation, allergic rhinitis, urticaria and insomnia. As an adjunct in pre-operative sedation in surgery and obstetrics. As a paediatric sedative
Promethazine is a phenothiazine derivative which blocks postsynaptic mesolimbic dopaminergic receptors in the brain. It exhibits strong α-adrenergic blocking effect and depresses the release of hypothalamic and hypophyseal hormones. It competes with histamine for the H1-receptor; muscarinic blocking effect may be responsible for antiemetic activity. It also reduces stimuli to the brainstem reticular system. Promethazine is well absorbed from the gastrointestinal tract. Clinical effects are apparent within 20 minutes after oral administration and generally last four to six hours, although they may persist as long as 12 hours. Promethazine is metabolized by the liver to a variety of compounds; the sulfoxides of promethazine and N-demethylpromethazine are the predominant metabolites appearing in the urine.
Always consult a registered doctor before taking any medicine. This information is for general knowledge only.
Adult: 25-50 mg by deep intramuscular injection or, in emergency, by slow intravenous injection after dilution of the 2.5% solution to 10 times its volume with water for injection. The maximum parenteral dose is 100 mg. Children: 5-10 years: 6.25 to 12.5 mg by deep I.M. Injection
Nervous system disorders: Frequency Unknown: Neuroleptic Malignant Syndrome the elderly are particularly susceptible to the anticholinergic efects and confusion due to Arromin, somnolence, dizziness, headaches, extrapyramidal efects including muscle spasm, tic-like movements of the head and face. A very serious and sometimes deadly health problem called neuroleptic malignant syndrome (NMS) may happen. Stop treatment and call your doctor right away if you have high fever, muscle cramps or stifness, dizziness, very bad headache, fast heartbeat, confusion, agitation, hallucinations, or are sweating a lot. Immune System Disorders- Frequency unknown: Allergic reactions, including urticaria, rash, pruritus, and anaphylaxis, have been reported. Skin and Subcutaneous Tissue Disorders- Frequency unknown: Photosensitivity reaction Metabolism and Nutrition Disorders- Frequency unknown: Anorexia Gastrointestinal Disorders- Frequency unknown: Epigastric discomfort, dry mouth Eye Disorders- Frequency unknown: Blurred vision Blood and Lymphatic System Disorders- Frequency unknown: Blood dyscrasias including hemolytic anemia, agranulocytosis Renal and Urinary Disorders- Frequency unknown: Urinary retention Psychiatric Disorders- Frequency unknown: Infants, newborns and premature are susceptible to the anticholinergic efects of promethazine, while other children may display paradoxical hyperexcitability, restlessness, nightmares, disorientation Cardiac Disorders- Frequency unknown: Palpitations, arrhythmias Vascular disorders- Frequency unknown: Hypotension Hepatobiliary disorders- Frequency unknown: Jaundice General Disorders and Administration Site Conditions- Frequency unknown: Tiredness Use Arromin only as recommended. Do not exceed the recommended dose. There have been case reports of promethazine abuse. Do not take for longer than 10 days.
Promethazine is contraindicated for use in children less than two years of age Hypersensitivity to promethazine or to any of the excipients. Phenergan should not be used in patients who are in a coma or suffering from CNS depression of any cause. It must not be given to neonates or premature infants. Phenergan should be avoided in patients who have been taking monoamine oxidase inhibitors within the previous 14 days
Arromin may enhance the action of any anticholinergic agent, tricyclic antidepressant, sedative or hypnotic, Alcohol should be avoided during drug treatment. Phenergan may interfere with immunologic urine pregnancy tests to produce false-positive or false-negative results. Phenergan should be discontinued at least 72 hours before the start of skin tests using allergen extracts as it may inhibit the cutaneous histamine response thus producing false-negative results.
The use of promethazine should be avoided in children and adolescents with signs and symptoms suggestive of Reye’s syndrome. Arromin may thicken or dry lung secretions and impair expectoration. It should therefore be used with caution in patients with asthma, bronchitis or bronchiectasis. Use with care in patients with severe coronary artery disease. Use with care in patients with narrow angle glaucoma. Use with care in patients with epilepsy. Use with care in patients with hepatic insufciency. Use with care in patients with renal insufciency. Caution should be exercised in patients with bladder neck obstruction. Caution should be exercised in patients with pyloro-duodenal obstruction.