Pethidine Hydrochloride

Pethidine is indicated for short-term (24-36 hours) relief of moderate to severe pain. It can be given via the following routes of administration: intramuscular, subcutaneous, slow intravenous bolus injection, intravenous infusion and patient controlled analgesia (PCA). Pethidine is indicated ... Read more Pethidine is indicated for short-term (24-36 hours) relief of moderate to severe pain. It can be given via the following routes of administration: intramuscular, subcutaneous, slow intravenous bolus injection, intravenous infusion and patient controlled analgesia (PCA). Pethidine is indicated for administration as an anaesthetic adjunct and for obstetric analgesia. An opioid antagonist and facilities for administration of oxygen and control of respiration should be immediately available during and immediately following intravenous administration of pethidine

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Brand NameDosage FormCompanyStrengthPrice

⊕Pethidine 50

Injection

Rephco Pharmaceuticals Ltd.

Gonoshasthaya Pharma Ltd.

50 mg/ml

৳34.5

per vial

1–2 of 2 brands

Clinical Information

Indications

For the temporary relief of nasal decongestiom due to the commomn cold, hay fever or other upper respiratpry allergies. Temporarily relieves nasal stuffiness. Decongests nasal passages: shrinks swollen membranes. Temporarily restores freer breathing through the nose. Helps decongest sinus openings and passages; temporarily relieves sinus congestion and pressure. Promotes nasal and/or sinus drainage. temporarily relieves sinus congestion and pressure.

Pharmacology

Pethidine is a phenylpiperidine derivative opioid analgesic. It acts mainly as mu-receptor agonist. Like most, opioid analgesics, it mimics endogenous opioids by activating opioid receptors in the central and peripheral nervous system. It reduces the release of neurotransmitter substances and also reduces the activity of postsynaptic neurons in the spinal cord thus preventing transmission of pain impulse.

Dosage & Administration

Adults and children 12 years of age and older: 1 bottle every 4-6 hours. Do not exceed 4 bottles in 24 hours. Children under 12: Do not use

Side Effects

Central Nervous System : Lightheadedness, dizziness, sedation, sweating, bizarre feelings, disorientation, hallucinations, psychosis. Some of these effects seem to be more prominent in ambulatory patients and those not experiencing severe pain, and may be relieved by reducing the dose slightly and lying down. Gastrointestinal : Nausea and vomiting, constipation.

⚕

Always consult a registered doctor before taking any medicine. This information is for general knowledge only.

Hypersensitivity to Pethidine. Respiratory depression, or where respiratory reserve is depleted (acute bronchial asthma, chronic airway disease, severe emphysema, severe chronic bronchitis, kyphoscoliosis). Head injury, raised intracranial pressure (apart form introducing monitoring and diagnostic problems, hypercapnia associated with respiratory depression can itself result in elevated intracranial pressure), brain tumour. Cardiac arrythmias, especially supraventricular tachycardias, cor pulmonale. Pethidine has a vagolytic action and may produce a significant increase in the ventricular response rate. Concurrent use of monoamine oxidase inhibitors (MAOI’s), including selegeline, or use of MAOI’s within two weeks prior. The combination of monoamine oxidase inhibitors and pethidine has caused hypotension, hypertension, excitation, rigidity, hyperpyrexia and/or convulsions and in some cases fatalities have been reported. This combination should be avoided. Pre-eclampsia, eclampsia. Convulsive states such as status epilepticus, tetanus and strychnine poisoning, due to the stimulatory effects of pethidine on the spinal cord. Diabetic acidosis where there is a danger of coma. Acute alcoholism or delirium tremens. Severe liver disease, incipient hepatic encephalopathy. Patients with a low platelet count, coagulation disorders or receiving anticoagulant treatment. Continuous Intravenous Infusion : The administration of pethidine via continuous intravenous infusion in patients with renal impairment is contraindicated. Patient-Controlled Analgesia : The administration of pethidine via patient-controlled analgesia (PCA) in young children and adults with poor cognitive function is contraindicated. The administration of pethidine via PCA in patients with renal impairment is contraindicated.

Precautions & Warnings

Do not exceed recommended dosage. If dizziness or sleeplessness occur, symptoms do not improve or are accompanied by a fever-consult a doctor. Do not exceed recommended dosage. If dizziness or sleeplessness occur, consult a doctor. Drug interaction Precaution: Do not use this product if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (Certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you are uncertain whether your prescription drug contains an MAOI, consult a health professional before using this product.