Oramycin is indicated in- Respiratory tract infections Mycoplasma pneumonia Urinary tract infections Sexually transmitted diseases: Infections due to Chlamydia trachomatis including uncom-plicated urethral, endocervical or rectal infections, non gonococcal urethritis, chancroid, granuloma inguinale, lymphogranuloma venereum, gonorrhoea, syphilis ... Read more Oramycin is indicated in- Respiratory tract infections Mycoplasma pneumonia Urinary tract infections Sexually transmitted diseases: Infections due to Chlamydia trachomatis including uncom-plicated urethral, endocervical or rectal infections, non gonococcal urethritis, chancroid, granuloma inguinale, lymphogranuloma venereum, gonorrhoea, syphilis Skin infections: Acne and rosacea Ophthalmic infections: Trachoma Rickettsial infections Other infections: Psittacosis, brucellosis, cholera, acute intestinal amoebiasis etc.
Oxytetracycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Oxytetracycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane.
Adults: 250-500 mg every 6 hours. Food, milk and some dairy products interfere with the absorption of Tetracyclines. So Tetracyclines should be given one hour before or two hours after meals.
Always consult a registered doctor before taking any medicine. This information is for general knowledge only.
Side effects of Oramycin, which have been reported in some patients, are anorexia, nausea, vomiting, diarrhoea, glossitis, skin rashes and urticaria.
Oxytetracycline should not be used with patients who are hypersensitive to Tetracyclines. It should not be used in children under 12 years of age. It is contraindicated in pregnant women because of tooth staining in the fetus and possible growth retardation effects.
Antacids containing Aluminium, Calcium, Magnesium, Zinc or Iron salts may impair the absorption of Oramycin. In long term therapy, Tetracyclines depress plasma prothrombin activity and reduced doses of concomitant anticoagulants may be necessary. A few cases of pregnancy or breakthrough bleeding have been attributed to the concurrent use of Tetracyclines or Oramycins with oral contraceptives.
Oramycin should be used with caution in renal impairment.