Nepafenac

N-Fenac TS 0.1% Ophthalmic Suspension: The treatment of post-operative ocular pain and inflammation including cataract surgery Inhibition of surgery induced miosis and Prevention of post-operative cystoid macular edema (CME). N-Fenac TS 0.3% Ophthalmic Suspension: Post-operative pain and inflammation associated with cataract surgery.

Nepafenac is a nonsteroidal anti-inflammatory prodrug (NSAID). After instillation in the eye, it penetrates the cornea and is converted by ocular tissue hydrolase to Amfenac, a potent nonsteroidal anti-inflammatory drug. Amfenac is thought to inhibit the action of cyclooxygenase enzyme. This enzyme is required for prostaglandin synthesis.

Nepafenac 0.1% Sterile Ophthalmic Suspension- For post-operative pain & inflammation: Instill 1 drop 3 times daily 1 day prior to cataract surgery and continued on the day of surgery and through the first 2 weeks of the post-operative period. For surgery induced miosis : Instill 1 drop 3 times daily 1 day before surgery & on the day of surgery. For prevention of post-operative CME: Instill 1 drop 3 times daily 1 day before surgery and continued on the day of surgery and through the first 6 weeks of the post-operative period. Nepafenac 0.3% Sterile Ophthalmic Suspension- For post-operative pain & inflammation: Instill 1 drop once daily 1 day prior to cataract surgery and continued on the day of surgery and through the first 2 weeks of the post-operative period. An additional drop should be administered 30 to 120 minutes prior to surgery. Use in children : Safety and effectiveness in pediatric patients below 18 years of age have not been established. Use in elderly patients : No overall differences in safety or effectiveness have been observed between elderly and younger patients.