Levocetirizine Dihydrochloride

Curin is indicated in the treatment of symptoms associated with allergic conditions such as- perennial allergic rhinitis seasonal allergic rhinitis chronic idiopathic urticaria

This preparation contains Levocetirizine Dihydrochloride. Levocetirizine is the active (Levo) isomer of cetirizine. It is a new highly effective and well-tolerated nonsedating antihistamine with potent antiallergic properties. It has a two-fold higher affinity for H1 receptors than cetirizine. Levocetirizine has a rapid and long-acting action, allowing once-a-day administration.

Adult and children 12 years of age and older : The recommended dose is 5 mg once daily. Children 6 to 11 years of age : The recommended dose is 2.5 mg (½ tablet or 1 teaspoon oral solution) once daily. Children 6 months to 5 years of age : The recommended dose is 1.25 mg (½ teaspoon oral solution) once daily. Pediatric use : The recommended dose for the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria in patients 6 months to 17 years of age is based on extrapolation of efficacy from adults 18 years of age and older. Geriatric use : In clinical studies, each approved indication did not include sufficient numbers of patients aged 65 years and older to determine whether they respond differently than younger patients. Hepatic impairment : No dosage adjustment is required in patients with solely hepatic impairment. Renal impairment : Mild renal impairment (creatinine clearance: 50-80 ml/min): a dose of 2.5 mg once daily is recommended. Moderate renal impairment (creatinine clearance: 30-50 ml/min): a dose of 2.5 mg once every other day is recommended. Severe renal impairment (creatinine clearance: 10-30 ml/min): a dose of 2.5 mg twice weekly (administered once every 3-4 days) is recommended. End-stage renal disease patients (creatinine clearance: <10 ml/min) and patients undergoing hemodialysis: should not receive Levocetirizine.