Zopilone is indicated for the managment of insomnia, Including difficulty in falling asleep, difficulty in maintaining sleep during the night, and waking up too early in the morning.
Eszopiclone (s-isomer of Zopiclone) is a sedative/hypnotic. It is a non-benzodiazepine that works via interaction with GABA-receptor complexes. It is rapidly absorbed and have elimination half-life (t 1/2 ) of approx. 6 hours in non-elderly adults. In the elderly, half life is approx. 9 hours.
Adult dose : The dose of Eszopiclone should be individualized. The recommended oral starting dose for most non-elderly adults (ages 18 to 64) is 2 mg immediately before bedtime. Dosing can be initiated at or increased to 3 mg as clinically indicated. The recommended oral starting dose for elderly patients ( ages 65 and older) who have difficulty falling asleep is 1 mg immediately before bedtime. In these patients, the dose may be increased to 2 mg as clinically indicated. For elderly patients who have difficulty staying asleep, the recommended dose is 2 mg immediately before bedtime. Pediatric dose : Pediatric dosing is not available. Taking Eszopiclone with or immediately after a heavy, high-fat meal results in slower absorption and would be expected to reduce the effect of Eszopiclone on sleep latency.
The most common side effects of sleep medicines are Drowsiness, dizziness, lightheadedness, hallucination, difficulty with coordination.
Always consult a registered doctor before taking any medicine. This information is for general knowledge only.
Depression, Severe Chronic Obstructive Lung Disease, Severe Liver Disease, Weakened Patient, Having thoughts of Suicide.
Alcohol (which causes sedation) and drugs that have sedating effects should not be used with Zopilone since their sedating effects, when added to those of Zopilone, may cause excessive sedation.
Zopilone should be administered with caution in patients exhibiting signs and symptoms of depression. Therefore, the smallest dose feasible should be prescribed to the patient. Caution should be exercised in administration of Zopilone to patients with compromised respiratory function. Use of benzodiazepines and similar agents may lead to physical and psychological dependence. Tolerance may develop after repeated use of benzodiazepines and benzodiazepine-like agents for a few weeks. However, no evidence of developed tolerance was seen with Zopilone over a period of 6 months in clinical trials. Safety information: Zopilone should only be taken immediatetly before bedtime. Patients should not engage in any activity after taking Zopilone that requires complete alertness , such as driving car or operating machinery etc. Patient should not use alcohol while taking Zopilone .