Ebastine

Alestin is indicated for the symptomatic treatment of: Seasonal and perennial allergic rhinitis. Chronic idiopathic urticaria.

Ebastine is a long-acting and selective H1-histamine receptor antagonist. After repeated administration, inhibition of peripheral receptors remains at a constant level. Ebastine is rapidly absorbed and undergoes extensive first-pass metabolism following oral administration. Ebastine is almost totally converted to the pharmacologically active acid metabolite, carebastine.

Tablet: Adults (more than 12 years of age) : 10 mg (one tablet) once daily. Children (6-12 years of age) : 5 mg (half tablet) once daily. Syrup: Children (2-5 years of age) : 2.5 ml once daily (upto 5 ml in severe cases such as Perennial Allergic Rhinitis). Children (6-12 years of age) : 5 ml once daily (upto 10 ml in severe cases such as Perennial Allergic Rhinitis). Ebastine may be taken with or without food.

The most common side-effects are headache, dry mouth and drowsiness. Less commonly reported side effects include abdominal pain, dyspepsia, nausea and insomnia.