Dextromethorphan Hydrobromide

Dixar is indicated in- Chronic dry cough Unproductive cough Acute dry cough which is interfering with normal function or sleep.

Dextromethorphan Hydrobromide is a cough suppressant which has a central action on the cough centre in the medulla. Although structurally related to morphine, it has no analgesic properties and in general it has little sedative activity. Addiction has not been observed after the administration of rather large doses for prolonged period. It is rapidly absorbed from the GI tract and exerts its effects in 15-30 minutes after oral administration. The duration of action is approximately 3-6 hours with conventional dosage form. Dextromethorphan hydrobromide is extensively metabolised in the liver and excreted in the urine as unchanged Dextromethorphan and demethylated metabolites including Dextrophan which has some cough suppressant activity. Urinary excretion of parent and metabolites accounts for up to 50% of the ingested dose over 24 hours. About 8% of the dose is excreted unchanged in the urine over the first 6 hours.

Adults and Children over 12 years : 15 to 30 mg three to four times per day. However, 60 mg doses up to four times per day have been used without increased side effects. Children between 6 and 12 years : 5-15 mg up to four times per day. Children between 2 and 6 years : 2.5-5 mg up to four times per day.

Adverse effects with Dixar are rare, but nausea and dizziness sometimes occur. The drug produces no analgesia or addiction and little or no CNS depression. Excitation, confusion and respiratory depression may occur after overdosage.