Dapsone

Dapgel is indicated for the topical treatment of acne vulgaris in patients 12 years of age and older.

Dapsone has both anti-infammatory and antimicrobial properties. A combination of these activities may account for its efcacy in acne. Anti-infammatory efects include inhibition of neutrophil myeloperoxidase and eosinophil peroxidase activity, suppression of hypochlorous acid production, scavenging of reactive oxygen species, suppression of neutrophil activity, and inhibition of chemoattractant-induced signal transduction. Antimicrobial activity, similar to that of sulfones and sulfonamides, is by inhibition of bacterial dihydropteroate synthase in the folic acid metabolic pathway. This mechanism is efective against microorganisms synthesizing their own folic acid. In vitro susceptibility testing has demonstrated some activity for Dapsone against Propionibacterium species, including Propionibacterium acnes (P. acnes).

Apply once daily (7.5% gel) and twice daily (5% gel) after the skin is gently washed and patted dry Apply approximately a pea-sized amount of gel in a thin layer to the acne affected area Rub the gel gently and completely If there is no improvement after 12 weeks, treatment with this gel should be reassessed Dapsone gel maybe gritty with visible drug substance particles Wash hands after application

Oiliness/peeiing, dryness and erythema at the application site.