Cybine may be used alone or in combination with other chemotherapeutic agents. It is indicated for induction of remission of leukaemia, particularly for acute myeloid leukaemia, in adults and children. Cybine has been used for remission induction in acute lymphocytic leukaemia, chronic myeloid ... Read more Cybine may be used alone or in combination with other chemotherapeutic agents. It is indicated for induction of remission of leukaemia, particularly for acute myeloid leukaemia, in adults and children. Cybine has been used for remission induction in acute lymphocytic leukaemia, chronic myeloid leukaemia and erythroleukaemia; and in the treatment and maintenance therapy of meningeal leukaemia and other meningeal neoplasms. Chiidren with non-Hodgkin's lymphoma have benefitted from a combination drug programme (LSA2L2) that includes Cybine.
Cytarabine is an antineoplastic agent. Cytarabine is a synthetic pyrimidine nucleoside, which is converted intracellularly to the nucleotide, cytarabine triphosphate. The exact mechanism of action of cytarabine is not fully understood, but cytarabine triphosphate appears to inhibit DNA synthesis by the inhibition of DNA polymerase. Cytarabine's actions are cell-cycle specific. Cytarabine is also immunosuppressant and has demonstrated antiviral activity in vitro.
Cytarabine Injection is not active orally. The schedule and method of administration varies with the program of therapy to be used. Cytarabine Injection may be given by intravenous infusion or injection, subcutaneously, or intrathecally (preservative free preparation only). In the induction therapy of acute non-lymphocytic leukemia, the usual cytarabine dose in combination with other anticancer drugs is 100 mg/m2/day by continuous IV infusion (1 to 7 Days) or 100 mg/m2 IV every 12 hours 1 to 7 Days). The literature should be consulted for the current recommendations for use in acute lymphocytic leukemia. Intrathecal Use in Meningeal Leukemia : Cytarabine injection has been used intrathecally in acute leukemia in doses ranging from 5 mg/m2 to 75 mg/m2 of body surface area. Use in Children : Appropriate studies with cytarabine have not been performed in the paediatric population. However, paediatric specific problems that would limit the usefulness of this medication in children are not expected. Use in the Elderly : Although studies with cytarabine have not been performed in the geriatric population, geriatric specific problems that would limit the usefulness of this medication in the elderly are not expected. Elderly patients are, however, more likely to have age related renal function impairment, which may require reduction of dosage in patients receiving cytarabine.
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The major adverse effect of Cybine is haematologic toxicity. Myelosuppression is normally manifested by megaloblastosis, leucopenia, anaemia, reticulocytopenia and thrombocytopenia. Leucopenia follows mainly from granulocyte depression; lymphocytes are minimally affected. The severity of these adverse effects is dependent on the dose of the drug and schedule of administration. Incidence and severity of haematologic toxicity is minimal after a single intravenous dose of Cybine, but myelosuppression occurs in almost all patients with daily IV injections or continuous IV infusions of the drug. Nausea and vomiting may occur in patients on Cybine therapy, and usually occur more frequently and severely following rapid IV administration as opposed to continuous infusion of the drug. Viral, bacterial, fungal parasitic or saprophytic infection which can be mild, severe and at times fatal, may be associated with the use of Cybine when used alone or in combination with other immunosuppressive agents following immunosuppressive doses that affect cellular or humoral immunity. Neurotoxicity following intrathecal Cybine has been associated with preservative containing diluents and many clinicians recommend the use of preservative free diluents instead. A Cybine syndrome characterised by fever, myalgia, bone pain, malaise, maculopapular rash, conjunctivitis, and occasionally chest pain, has been reported. A "flu-like" syndrome has been reported, which may be treated with corticosteroid therapy if severe. Anaphylactoid reactions have occurred. It normally occurs at 6 to 12 hours after administration of the drug; corticosteroids have been shown to be of benefit in the treatment and prevention of the syndrome. If treatment of the symptoms of the syndrome is required, administration of corticosteroids should be considered, as well as continuation of Cybine therapy. Two patients with adult non lymphocytic leukaemia developed peripheral motor and sensory neuropathies after consolidation with high dose Cybine, daunorubicin and asparaginase. A syndrome of sudden respiratory distress, rapidly progressing to pulmonary oedema and radiologically pronounced cardiomegaly has been reported following experimental high dose therapy of Cybine for relapsed leukaemia. This syndrome can have fatal consequences.
Cytarabine is contraindicated in patients with known hypersensitivity to the drug.
May reduce efficacy of 5-fluorocytosine, digoxin, gentamicin. May increase risk of neurotoxicity with other cytotoxic agents (intrathecal).
Patient with previous drug-induced bone marrow suppression. Renal or hepatic impairment. Pregnancy and lactation.