Cyanocobalamin

Cynovit is indicated in Pernicious anemia, Vitamin B12 deficiency due to low intake from food, Thyrotoxicosis, Hemorrhage, Malignancy, Liver or kidney disease, Gastric bypass surgery, total or partial gastrectomy, Gluten enteropathy or sprue, folic acid deficiency, macrocytic anaemia.

Vitamin B12 (cyanocobalamin) is required for the maintenance of normal erthropoiesis, nucleprotein and myelin synthesis, cell reproduction and normal growth; Coenzyme; metabolic functions include protein synthesis and carbohydrate metabolism. Plays role in cell replication and hematopoiesis.

Usual Adult Dose for Pernicious Anemia Initial dose : 1000 mcg intramuscularly or deep subcutaneous once a day for 6 to 7 days If clinical improvement and reticulocyte response is seen from the above dosing: 100 mcg every other day for 7 doses, then 100 mcg every 3 to 4 days for 2 to 3 weeks, then Maintenance dose: 100 to 1000 mcg monthly Administer concomitant folic acid if needed. Chronic treatment should be done with an oral preparation in patients with normal intestinal absorption. Usual Adult Dose for B12 Nutritional Deficiency : 25 to 2000 mcg orally daily Usual Adult Dose for Schilling Test : 1000 mcg intramuscularly is the flushing dose Usual Pediatric Dose for B12 Nutritional Deficiency : 0.5 to 3 mcg daily

Arthralgia (12%), Dizziness (12%), Headache (12%), Nasopharyngitis (12%), Anaphylaxis, Angioedema, Congestive heart failure, Peripheral vascular disease,Pulmonary edema, Diarrhea, Dyspepsia, Polycythemia vera, Sore throat, Nervousness, Rhinitis, Glossitis, Hypoesthesia