Cabretol is indicated for- Partial and secondary generalized tonic-clonic seizures Primary generalized tonic-clonic seizures Trigeminal neuralgia Prophylaxis of bipolar disorder
Carbamazepine depresses activity in the nucleus ventralis of the thalamus, reduces synaptic propagation of excitatory impulses or decreases summation of temporal stimulation leading to neural discharge by limiting influx of Na ions across cell membrane or other unknown mechanisms. It stimulates the release of antidiuretic hormone (ADH) and potentiates its action in promoting reabsorption of water.
Epilepsy: Adults and children over 12 years of age
Always consult a registered doctor before taking any medicine. This information is for general knowledge only.
The common side effects are dizziness, drowsiness, ataxia, dry mouth, abdominal pain, nausea, vomiting, anorexia, leucopenia, proteinuria, bradycardia, heart failure and hypotension. Erythematous skin rash, aplastic anemia may also be observed. The most severe adverse reactions have been observed in the hemopoietic system, the skin and the cardiovascular system.The most frequently observed adverse reactions, particularly during the initial phases of therapy, are dizziness, drowsiness, unsteadiness, nausea, and vomiting. This medicine may cause increased sensitivity to the sun. Exposure to the sun, sunlamps, or tanning booths should be avoided if the increased sensitivity is seen. A sunscreen or protective clothing may be helpful at outside for a prolonged period.
This medicine should not be used if anybody is allergic to one or any of its ingredients. It can not be used also in the following conditions: Problems with the electrical message pathways in the heart (atrioventricular block) History of decreased blood cell production by the bone marrow (bone marrow depression) Hereditary blood disorders called porphyrias Allergy to tricyclic antidepressants People who have taken a monoamine-oxidase inhibitor antidepressant (MAOI) in the last 14 days
Galactorrhoea has been reported in few women on oral contraceptives within the first two months of Cabretol treatment Hepatic enzyme inducers such as Cabretol and Phenytoin may interact with Cabretol by increasing its metabolism. So an increase in dosage of Cabretol may be required.
This medicine may cause dizziness and drowsiness.Special care should be taken while performing potentially hazardous activities, such as driving or operating machinery. This medicine may cause skin reactions. If any rash,skin peeling, itching, or other unexplained skin reaction is seen while taking this medicine the concerned doctor should be informed immediately. This medicine may rarely cause liver problems.For this reason, consultation with doctor is needed if unexplained itching, yellowing of the skin or eyes, unusually dark urine, nausea and vomiting, abdominal pains, and loss of appetite or flu-like symptoms. Cabretol decreases the blood levels of hormonal contraceptives containing estrogen and/or progesterone, which may make the contraceptive ineffective or result in breakthrough bleeding. Women taking this medicine who require contraception should be prescribed a contraceptive containing at least 50 micrograms of oestrogen,or use non-hormonal methods of contraception, such as condoms. Taking this medicine should not be stopped suddenly unless the doctor tells. Otherwise, as suddenly stopping treatment is likely to make the symptoms return.If this medicine is stopped, it should normally be done gradually, under the supervision of a specialist. Caution should be taken in- Mixed seizures including absence seizures Elderly people History of heart disease History of kidney disease History of liver disease History of psychotic illness Raised pressure in the eye (intraocular pressure), eg.glaucoma History of blood disorders that were caused by any other medication History of previous Cabretol therapy that was interrupted due to side effects or allergy