Diacana is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Canagliflozin is an inhibitor of subtype-2 sodium-glucose co-transport protein (SGLT2), which is responsible for at least 90% of the glucose reabsorption in the kidney. Blocking this transporter reduces the reabsorption of glucose from renal tubules, leading to more excretion of glucose in urine.
The recommended starting dose is 100 mg once daily, taken before the first meal of the day. Dose can be increased to 300 mg once daily who have CrCl>60 ml/min or who requires additional glycemic control. No dose adjustment is required for mild renal impairment. For moderate renal impairment (CrCl 45-60 ml/min) Canagliflozin 100 mg is recommended.
The most common adverse reactions of Diacana are female genital mycotic infections, urinary tract infection and increased urination. Other side effects of Diacana include low blood pressure, increases potassium blood levels (hyperkalemia), low blood glucose and increases Low-Density Lipoprotein (LDL-C).
Always consult a registered doctor before taking any medicine. This information is for general knowledge only.
History of serious hypersensitivity reaction to Canagliflozin, severe renal impairment, End Stage Renal Disease (ESRD), or on dialysis patients.
UGT inducers (e.g. rifampin, phenytoin) : Diacana exposure is reduced. Consider increasing dose from 100 mg to 300 mg. Digoxin : Diacana may slightly increase the concentration of digoxin in the body when both drugs are being taken.
Not for the treatment of type 1 diabetes mellitus or diabetic ketoacidosis.