Treatment of Thrombocytopenia in Patients with Chronic Liver Disease (CLD) : Avalet is indicated for the treatment of thrombocytopenia in adult patients with chronic liver disease who are scheduled to undergo a procedure. Treatment of Thrombocytopenia in Patients with Chronic Immune Thrombocytopenia (ITP) ... Read more Treatment of Thrombocytopenia in Patients with Chronic Liver Disease (CLD) : Avalet is indicated for the treatment of thrombocytopenia in adult patients with chronic liver disease who are scheduled to undergo a procedure. Treatment of Thrombocytopenia in Patients with Chronic Immune Thrombocytopenia (ITP) : Avalet is indicated for the treatment of thrombocytopenia in adult patients with chronic immune thrombocytopenia who have had an insufficient response to a previous treatment.
Mechanism of Action: Avatrombopag is an orally bioavailable, small molecule TPO receptor agonist that stimulates proliferation and differentiation of megakaryocytes from bone marrow progenitor cells resulting in an increased production of platelets. Avatrombopag does not compete with TPO for binding to the TPO receptor and has an additive effect with TPO on platelet production. Pharmacodynamics: Platelet Response: Avatrombopag resulted in dose- and exposure-depen- dent elevations in platelet counts in adults. The onset of the platelet count increase was observed within 3 to 5 days of the start of a 5-day treatment course, with peak effect observed after 10 to 13 days. Subsequently, platelet counts decreased gradually, returning to near baseline values after 35 days. Pharmacodynamics: Cardiac Electrophysiology: At exposures similar to that achieved at the 40 mg and 60 mg dose, Avatrombopag did not prolong the QT interval to any clinically relevant extent. Mean QTc prolongation effects >20 ms are not anticipated with the highest recommended therapeutic dosing regimen based on analysis of data from the pooled clinical trials in patients.
Always consult a registered doctor before taking any medicine. This information is for general knowledge only.
Recommended Dosage for Patients with Chronic Liver Disease: Recommended Dose and Duration in Patients with Chronic Liver Disease Scheduled to Undergo a Procedure- Platelet count less than 40X10 9 /L: 60 mg (3 tablets) for 5 days Platelet count 40 to less than 50X10 9 /L: 40 mg (2 tablets) for 5 days Recommended Dosage for Patients with Chronic Immune Thrombocytopenia: Initial Dose Regimen: Begin Avatrombopag at a starting dose of 20mg (1tablet) once daily with food. Avatrombopag Dose Adjustments for Patients with Chronic Immune Thrombocytopenia- Less than 50 after at least 2 weeks of Avatrombopag x 10 9 /L : Increase One Dose Level. Wait 2 weeks to assess the effects of this regimen and any subsequent dose adjustments. Between 200 and 400 x 10 9 /L : Decrease One Dose Level. Wait 2 weeks to assess the effects of this regimen and any subsequent dose adjustments. Greater than 400 x 10 9 /L : Stop Avatrombopag. Increase platelet monitoring to twice weekly. When platelet count is less than 150 x10 9 /L, decrease One Dose Level per Table 3 and reinitiate therapy. Less than 50 after 4 weeks of Avatrombopag 40 mg once daily x 10 9 /L : Discontinue Avatrombopag. Greater than 400 after 2 weeks of Avatrombopag 20 mg weekly x 10 9 /L : Discontinue Avatrombopag. Or, as directed by the registered physician.
In patients with chronic liver disease, the most common adverse reactions were pyrexia, abdominal pain, nausea, headache, fatigue, and edema peripheral. In patients with chronic immune thrombocytopenia, the most common adverse reactions were headache, fatigue, confusion, epistaxis, upper respiratory tract infection, arthralgia, gingival bleeding, petechiae and nasopharyngitis.
It is contraindicated in patients with hypersensitivity to Avatrombopag or any component of this product.
Effect of Other Drugs on Avalet in Patients with Chronic Immune Thrombocytopenia. Moderate or Strong Dual Inhibitors of CYP2C9 and CYP3A4 : Concomitant use with a moderate or strong dual inhibitor of CYP2C9 and CYP3A4 increases Avalet AUC, which may increase the risk of Avalet toxicities. Reduce the starting dosage of Avalet when used concomitantly with a moderate or strong dual inhibitor of CYP2C9 and CYP3A4. Moderate or Strong Dual Inducers of CYP2C9 and CYP3A4 : Concomitant use with a moderate or strong dual inducer of CYP2C9 and CYP3A4 decreases Avalet AUC, which may reduce Avalet efficacy. Increase the recommended starting dosage of Avalet when used concomitantly with a moderate or strong dual inducer of CYP2C9 and CYP3A4.
Thrombotic/Thromboembolic Complications : Avalet is a thrombopoietin (TPO) receptor agonist and TPO receptor agonists have been associated with thrombotic and thromboembolic compli- cations in patients with chronic liver disease. Portal vein thrombosis has been reported in patients with chronic liver disease treated with TPO receptor agonists. In the ADAPT-1 and ADAPT-2 clinical trials, there was 1 treatment-emergent event of portal vein thrombosis in a patient (n=1/430) with chronic liver disease and thrombocytopenia treated with Avalet. Consider the potential increased thrombotic risk when administering Avalet to patients with known risk factors for thromboembolism, including genetic prothrombotic conditions (Factor V Leiden, Prothrombin 20210A, Antithrombin deficiency or Protein C or S deficiency). Avalet should not be administered to patients with chronic liver disease in an attempt to normalize platelet counts.