Aripen is indicated for- Schizophrenia Bipolar disorder Adjunctive treatment of major depressive disorder Irritability associated with autistic disorder Agitation associated with schizophrenia or bipolar mania
Aripiprazole is an atypical antipsychotic and it has been proposed that the efficacy of Aripiprazole is mediated through a combination of partial agonist activity at Dopamine D2 and Serotonin 5-HT 1A receptors and antagonist activity at Serotonin 5-HT 2A receptors. This is associated with improvement of schizophrenia, bipolar disorder, major depressive disorder, irritability associated with autistic disorder, and agitation associated with schizophrenia or bipolar disorder.
Schizophrenia : adults Initial Dose: 10-15 mg/day Recommended Dose: 10-15 mg/day Maximum Dose: 30 mg/day Schizophrenia : adolescents (ages 13-17 years) Initial Dose: 2 mg/day Recommended Dose: 10 mg/day Maximum Dose: 30 mg/day Bipolar mania : adults: monotherapy Initial Dose: 15 mg/day Recommended Dose: 15 mg/day Maximum Dose: 30 mg/day Bipolar mania : adults: adjunct to lithium or valproate Initial Dose: 10-15 mg/day Recommended Dose: 15 mg/day Maximum Dose: 30 mg/day Bipolar mania : pediatric patients (ages 10-17 years): monotherapy or as an adjunct to lithium or valproate Initial Dose: 2 mg/day Recommended Dose: 10 mg/day Maximum Dose: 30 mg/day As an adjunct to antidepressants for the treatment of major depressive disorder : adults Initial Dose: 2-5 mg/day Recommended Dose: 5-10 mg/day Maximum Dose: 15 mg/day Irritability associated with autistic disorder : pediatric patients (ages 6-17 years): Initial Dose: 2 mg/day Recommended Dose: 5-10 mg/day Maximum Dose: 15 mg/day
Always consult a registered doctor before taking any medicine. This information is for general knowledge only.
Vomiting, nausea, akathisia, extrapyramidal disorder, somnolence, sedation, dizziness, insomnia, tremor, restlessness, fatigue, blurred vision, salivary hypersecretion, constipation, pyrexia, drooling, decreased appetite.
Known hypersensitivity to Aripiprazole.
Caution should be exercised when Aripen is taken in combination with other centrally acting drugs and alcohol. Carbamazepine could cause an increase in Aripen clearance and lower blood levels. Ketoconazole, quinidine, fluoxetine or paroxetine can inhibit Aripen elimination and cause increased blood levels.
Elderly Patients with Dementia-Related Psychosis : Increased incidence of cerebrovascular adverse events (eg, stroke, transient ischemic attack, including fatalities). Suicidality & antidepressants : Increased risk of suicidality in children, adolescents, young and adults with major depressive disorder. Tardive dyskinesia : Discontinue if clinically appropriate. Metabolic changes : Atypical antipsychotic drugs have been associated with metabolic changes that include hyperglycemia/diabetes mellitus, dyslipidemia, and body weight gain. Orthostatic hypotension : Use with caution in patients with known cardiovascular or cerebrovascular disease. Seizures/Convulsions : Use cautiously in patients with a history of seizures. Use caution when operating machinery.