Apridex is indicated for- Prevention of postoperative nausea and vomiting (PONV) Prevention of Chemotherapy induced nausea and vomiting (CINV)
Aprepitant is a selective high affinity antagonist of human substance P neurokinin 1 (NK1) receptors. When substance P attaches to these receptors, it causes nausea and vomiting. Aprepitant stops substance P from binding to the NK1 receptors. By blocking the receptors, Aprepitant can prevent nausea and vomiting, which often happens after chemotherapy or as a complication of surgery.
Post Operative Nausea and Vomiting : The recommended oral dosage of Aprepitant is 40 mg within 3 hours prior to induction of anesthesia. Chemotherapy-Induced Nausea and Vomiting : The following regimen should be used for the prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy- Day 1 : Aprepitant 125 mg orally, Dexamethasone 12 mg orally, 5-HT3 antagonist (Ondansetron): 24 mg 30 minutes before the start of chemotherapy. Day 2 : Aprepitant 80 mg orally, Dexamethasone 8 mg orally Day 3 : Aprepitant 80 mg orally, Dexamethasone 8 mg orally Day 4 : Dexamethasone 8 mg orally Aprepitant is administered orally 1 hour prior to chemotherapy treatment on Day 1 and in the morning on Days 2 and 3. Dexamethasone is administered 30 minutes prior to chemotherapy treatment on Day 1 and in the morning on Days 2 through 4. The dose of dexamethasone accounts for drug interactions. The following regimen should be used for the prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy: Day 1 : Aprepitant 125 mg orally, Dexamethasone 12 mg orally, 5-HT3 antagonist (Ondansetron): one 8 mg tablet 30 minutes before chemotherapy followed by an 8 mg dose 8 hours later. Day 2 : Aprepitant 80 mg orally, 5-HT3 antagonist (Ondansetron): 8 mg tablet twice a day Day 3 : Aprepitant 80 mg orally, 5-HT3 antagonist (Ondansetron): 8 mg tablet twice a day. Aprepitant is administered orally 1 hour prior to chemotherapy treatment on Day 1 and in the morning on Days 2 and 3. Dexamethasone is administered 30 minutes prior to chemotherapy treatment on Day 1. The dose of dexamethasone accounts for drug interactions. Aprepitant may be taken with or without food. No dosage adjustment is necessary for the elderly patients.
Always consult a registered doctor before taking any medicine. This information is for general knowledge only.
Constipation, Hypotension, Pruritus, Pyrexia
Aprepitant is contraindicated in patients who are hypersensitive to any component of the product. Aprepitant should not be used concurrently with Pimozide, Terfenadine, Astemizole & Cisapride.
Apridex is a substrate, a weak-to-moderate (dose dependent) inhibitor, and an inducer of CYP3A4. Apridex is also an inducer of CYP2C9. Precautions should be taken while coadministering Apridex with drugs that use CYP3A4 or CYP2C9, for example- Warfarin, Tolbutamide, Phenytoin, Ketoconazole, Itraconazole, Nefazodone, Troleandomycin, Clarithromycin, Ritonavir, Nelfinavir, Diltiazem, Rifampin, Carbamazepine etc. Upon coadministration with Apridex, the efficacy of hormonal contraceptives during and for 28 days following the last dose of Apridex may be reduced. Alternative or back-up methods of contraception should be used during treatment with Apridex and for 1 month following the last dose of Apridex.