Antif is indicated in the treatment of infections due to susceptible ß-lactamase negative strains of microorganisms. These infections include Ear, nose and throat infections (i.e. otitis media, sinusitis, tonsillitis, pharyngitis, laryngitis) Lower respiratory tract infections (i.e. pneumonia, acute and chronic bronchitis lung abscess, empyema, bronchiectasis) ... Read more Antif is indicated in the treatment of infections due to susceptible ß-lactamase negative strains of microorganisms. These infections include Ear, nose and throat infections (i.e. otitis media, sinusitis, tonsillitis, pharyngitis, laryngitis) Lower respiratory tract infections (i.e. pneumonia, acute and chronic bronchitis lung abscess, empyema, bronchiectasis) Skin and soft tissue infections (i.e. cellulitis, carbuncles, furunculosis, infected wounds, abscess) Genito-urinary tract infections (i.e. pyelonephritis, cystitis and urethritis) Venereal disease (i.e. acute uncomplicated gonorrhoea) In dental abscess, it is used as short-term therapy. It is also indicated in combination with Clarithromycin and Lansoprazole (as triple therapy), for the treatment of patients with H. pylori infection and duodenal ulcer disease and to reduce the risk of duodenal ulcer recurrence.
Amoxicillin is a broad spectrum penicillin. It is effective against a wide range of Gram-positive and Gram-negative bacteria. It acts through the inhibition of biosynthesis of cell wall. Amoxicillin is stable in the presence of gastric acid and is rapidly absorbed after oral administration. After an oral dose, peak plasma concentration of Amoxicillin is reached within 1 to 2 hours. Amoxicillin is widely distributed at varying concentration in body tissues and fluids.
Adult : 250 mg three times daily, increasing up to 500 mg three times daily for severe infections. Children (up to 10 years of age) : 125 mg three times daily, increasing up to 250 mg three times daily for severe infections. Severe or recurrent purulent respiratory infection : 3 gm every 12 hours. Otitis media : Recommended dose is 1 g three times daily for adult and 40 mg/kg body weight daily in 3 divided doses for children (max. 3 g daily). Pneumonia : Recommended dose is 500-1000 mg three times daily. Dental abscess : Recommended dose is 3 gm, repeated after 10-12 hours. Urinary tract infections : Recommended dose is 3 gm, repeated after 10-12 hours. Gonorrhoea : Single dose of 2-3 gm with Probenecid 1 gm is recommended (Probenecid is contraindicated in children under 2 years). In renal impairment : it may be necessary to reduce the total daily dosage.
Always consult a registered doctor before taking any medicine. This information is for general knowledge only.
Side effects are mild and transient in nature. This may include diarrhoea, indigestion or occasionally rash. Pseudo-membranous colitis has been reported rarely.
Amoxicillin is contraindicated in penicillin hypersensitive patients.
Concurrent use of Antif and Probenecid may result in increased and prolonged blood levels of Antif. Antif may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.
The possibility of superinfections with mycotic or bacterial pathogens should be kept in mind during therapy. If superinfections occur, Antif should be discontinued and appropriate therapy should be instituted.